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Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia

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Recent Advances in Cell Biology of Acute Leukemia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 131))

Abstract

Mature human T lymphocytes recognize self and non-self through two distinct types of T-cell antigen receptors (TCR), TCRαβ and TCRγδ, that are expressed on the cell surface membrane in association with CD3 molecules (reviewed by Davis and Bjorkman 1988; Brenner et al. 1988). Inappropriate pairing of TCR chains, e.g. βδ, or surface expression of single chains apparently does not occur in normal T cells, although such phenomena have been described as rare events in leukemic cell lines (Hochstenbach and Brenner 1989).

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Author information

Authors and Affiliations

  1. Division of Bone Marrow Transplantation, Department of Hematology-Oncology, St. Jude Children’s Research Hospital, Memphis, TN, 38101, USA

    D. Campana & E. Coustan-Smith

  2. Department of Pathology and Laboratory Medicine, St. Jude Children’s Research Hospital, Memphis, TN, 38101, USA

    F. G. Behm

  3. Department of Virology, St. Jude Children’s Research Hospital, Memphis, TN, 38101, USA

    R. Goorha

Authors
  1. D. Campana
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  2. E. Coustan-Smith
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  3. F. G. Behm
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  4. R. Goorha
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Editor information

Editors and Affiliations

  1. Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Hindenburgdamm 30, W-1000, Berlin 45, Germany

    Wolf-Dieter Ludwig  & Eckhard Thiel  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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Campana, D., Coustan-Smith, E., Behm, F.G., Goorha, R. (1993). Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia. In: Ludwig, WD., Thiel, E. (eds) Recent Advances in Cell Biology of Acute Leukemia. Recent Results in Cancer Research, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84895-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-84895-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84897-1

  • Online ISBN: 978-3-642-84895-7

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