Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia
Mature human T lymphocytes recognize self and non-self through two distinct types of T-cell antigen receptors (TCR), TCRαβ and TCRγδ, that are expressed on the cell surface membrane in association with CD3 molecules (reviewed by Davis and Bjorkman 1988; Brenner et al. 1988). Inappropriate pairing of TCR chains, e.g. βδ, or surface expression of single chains apparently does not occur in normal T cells, although such phenomena have been described as rare events in leukemic cell lines (Hochstenbach and Brenner 1989).
KeywordsTerminal Deoxynucleotidyl Transferase Leukemic Blast Cytocentrifuge Preparation Case Blast TCRa Gene
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