Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia
Mature human T lymphocytes recognize self and non-self through two distinct types of T-cell antigen receptors (TCR), TCRαβ and TCRγδ, that are expressed on the cell surface membrane in association with CD3 molecules (reviewed by Davis and Bjorkman 1988; Brenner et al. 1988). Inappropriate pairing of TCR chains, e.g. βδ, or surface expression of single chains apparently does not occur in normal T cells, although such phenomena have been described as rare events in leukemic cell lines (Hochstenbach and Brenner 1989).
KeywordsAcetone Lymphoma Leukemia Fluorescein Paration
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- Coustan-Smith E, Behm FG, Goorha R, Campana D (Manuscript in preparation) Promiscuous T cell receptor protein expression in normal and malignant human T cells.Google Scholar
- Furley AJ, Mizutani S, Weilbaecher K, Dhalival HS, Ford AM, Chan LC, Molgaard HV, Toyonaga B, Mak T, Van der Elsen P, Gold D, Terhorst C, Greaves MG (1986) Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex. Cell 46: 75PubMedCrossRefGoogle Scholar
- Rivera GK, Raimondi SC, Hancock ML, Behm FG, Pui C-H, Abromovitch M, Mirro J, Ochs JS, Look AT, Williams DL, Murphy SB, Dahl GV, Kalwinsky DK, Evans WE, Kun LE, Simone JV, Crist WM (1991) Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet i: 61Google Scholar
- Van Dongen JJM, Quertermous T, Bartram CR, Gold DP, Wolvers-Tettero ILM, Comans-Bitter WM, Hooijkaas H, Adriaansen HJ, De Klein A, Raghavachar A, Ganser A, Duby AD, Seidman JG, Van der Elsen P, Terhorst C (1987) T cell receptor-CD3 complex during early T cell differentiation. Analysis of immature T cell acute lymphoblastic leukemias at DNA, RNA, and cell membrane level. J Immunol 138: 1260PubMedGoogle Scholar