Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia

  • D. Campana
  • E. Coustan-Smith
  • F. G. Behm
  • R. Goorha
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 131)


Mature human T lymphocytes recognize self and non-self through two distinct types of T-cell antigen receptors (TCR), TCRαβ and TCRγδ, that are expressed on the cell surface membrane in association with CD3 molecules (reviewed by Davis and Bjorkman 1988; Brenner et al. 1988). Inappropriate pairing of TCR chains, e.g. βδ, or surface expression of single chains apparently does not occur in normal T cells, although such phenomena have been described as rare events in leukemic cell lines (Hochstenbach and Brenner 1989).


Terminal Deoxynucleotidyl Transferase Leukemic Blast Cytocentrifuge Preparation Case Blast TCRa Gene 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • D. Campana
    • 1
  • E. Coustan-Smith
    • 1
  • F. G. Behm
    • 2
  • R. Goorha
    • 3
  1. 1.Division of Bone Marrow Transplantation, Department of Hematology-OncologySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of Pathology and Laboratory MedicineSt. Jude Children’s Research HospitalMemphisUSA
  3. 3.Department of VirologySt. Jude Children’s Research HospitalMemphisUSA

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