Incidence and Prognostic Significance of Immunophenotypic Subgroups in Childhood Acute Lymphoblastic Leukemia: The Experience of the AIEOP Cooperative Study
The role of immunological phenotype in childhood acute lymphoblastic leukemia’s (ALL) is important in classifying the different origins of ALL, but the identification of different subgroups of clinical relevance is still under discussion. In fact, frequent discrepancies are observed in the prognostic value of immunological subgroups in individual series. A poor outcome was seen in immunophenotype T in the first clinical studies (Greaves et al. 1981), but these results have not always been confirmed and now the T origin of ALL is not considered a prognostic factor (Hammond et al. 1986).
KeywordsLeukemia Corticosteroid Oncol Methotrexate Cyclophosphamide
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