Combined Chemo-Radiotherapy with Carboplatin, 5-Fluorouracil and Folinic Acid for Cancer of the Urinary Bladder: Acute and Late Side Effects
Conventional treatment of advanced bladder carcinoma included surgery, or preoperative irradiation combined with surgery. Results of cystectomy alone and irradiation/surgery for T3 tumors achieved 5-year survival rates up to 40% (Jacobi et al. 1983) and 40%–50% (van der Werf-Messing 1983). 5-Fluorouracil (5-FU), mitomycin C and cisplatin were shown to be useful as radiosensitizers in invasive bladder carcinoma. Rotman et al. (1987) and Russel et al. (1988) demonstrated an advantage for 5-year disease-free survival using irradiation and chemotherapy with 5-FU and mitomycin C. Sauer et al. (1988) and Shipley et al. (1984, 1985) reported similarly complete response rates with cisplatin and irradiation. However, cisplatin is a potentially more toxic drug, especially as regards its neurotoxicity and nephrotoxicity (Lelieveld et al. 1984).
KeywordsTransitional Cell Carcinoma Folinic Acid Bladder Carcinoma Late Side Effect Acute Side Effect
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- Arbuck SG (1989) Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer. Cancer [Suppl] 63: 1036–1044Google Scholar
- Marks BL, Kaufman SD, Prout G, Heney NM, Griffin PP, Shipley WU (1988) Invasive bladder carcinoma: preliminary report of selective bladder conservation by transurethral surgery, upfront MCV chemotherapy and pelvic irradiation plus cisplatin. Int J Radiat Oncol Biol Phys 15: 877–883PubMedCrossRefGoogle Scholar
- Russel KJ, Boileau MA, Ireton R (1988) Transitional cell carcinoma of the urinary bladder: histologic clearance with combined 5-FU chemotherapy and radiation therapy: preliminary results of a bladder-preservation study. Radiology 167: 845–850Google Scholar
- Van der Werf-Messing B (1983) Carcinoma of the bladder treated by preoperative irradiation followed by cystectomy. Cancer 32: 1084–1088Google Scholar