Combined Chemo-Radiotherapy with Carboplatin, 5-Fluorouracil and Folinic Acid for Cancer of the Urinary Bladder: Acute and Late Side Effects

  • T. Wiegel
  • J. Lorenzen
  • W.-P. Brockmann
  • B. Lopez
  • R. Schwarz
  • K.-H. Hübener
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 130)

Abstract

Conventional treatment of advanced bladder carcinoma included surgery, or preoperative irradiation combined with surgery. Results of cystectomy alone and irradiation/surgery for T3 tumors achieved 5-year survival rates up to 40% (Jacobi et al. 1983) and 40%–50% (van der Werf-Messing 1983). 5-Fluorouracil (5-FU), mitomycin C and cisplatin were shown to be useful as radiosensitizers in invasive bladder carcinoma. Rotman et al. (1987) and Russel et al. (1988) demonstrated an advantage for 5-year disease-free survival using irradiation and chemotherapy with 5-FU and mitomycin C. Sauer et al. (1988) and Shipley et al. (1984, 1985) reported similarly complete response rates with cisplatin and irradiation. However, cisplatin is a potentially more toxic drug, especially as regards its neurotoxicity and nephrotoxicity (Lelieveld et al. 1984).

Keywords

Toxicity Anemia Oncol Diarrhea Doxorubicin 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • T. Wiegel
    • 1
  • J. Lorenzen
    • 1
  • W.-P. Brockmann
    • 1
  • B. Lopez
    • 2
  • R. Schwarz
    • 1
  • K.-H. Hübener
    • 1
  1. 1.Department of RadiotherapyUniversity Hospital Hamburg-EppendorfHamburgFed. Rep. of Germany
  2. 2.Department of UrologyGeneral Hospital Hamburg-EilbekFed. Rep. of Germany

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