Combined Chemo-Radiotherapy with Carboplatin, 5-Fluorouracil and Folinic Acid for Cancer of the Urinary Bladder: Acute and Late Side Effects
Conventional treatment of advanced bladder carcinoma included surgery, or preoperative irradiation combined with surgery. Results of cystectomy alone and irradiation/surgery for T3 tumors achieved 5-year survival rates up to 40% (Jacobi et al. 1983) and 40%–50% (van der Werf-Messing 1983). 5-Fluorouracil (5-FU), mitomycin C and cisplatin were shown to be useful as radiosensitizers in invasive bladder carcinoma. Rotman et al. (1987) and Russel et al. (1988) demonstrated an advantage for 5-year disease-free survival using irradiation and chemotherapy with 5-FU and mitomycin C. Sauer et al. (1988) and Shipley et al. (1984, 1985) reported similarly complete response rates with cisplatin and irradiation. However, cisplatin is a potentially more toxic drug, especially as regards its neurotoxicity and nephrotoxicity (Lelieveld et al. 1984).
KeywordsToxicity Anemia Oncol Diarrhea Doxorubicin
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