Abstract
The aim of curative radiation oncology is to destroy all tumor cells without producing major damage in normal tissues. As early as 1936 the radiologist Hermann Holthusen related such uncomplicated local tumor control to tumor response on the one hand and normal tissue tolerance on the other (Fig. 1). Holthusen showed that both the probability of eradicating carcinoma of the skin and the probability of developing telangiectasia as a late normal tissue reaction increase as a sigmoid function of radiation dose. At each dose level the probability of uncomplicated local tumor control can be calculated as the product of the probability of achieving local tumor control and the probability of preventing normal tissue damage (Holthusen 1936; Busch 1987).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bentzen SM, Johansen LV, Overgaard J, Thames HD (1991) Clinical radiobiology of squamous cell carcinoma of the oropharynx. Int J Radiat Oncol Biol Phys 20: 1197–1206
Busch M (1987) Risiken und Heilungschancen bei der Tumortherapie. In: Scherer E (ed) Strahlentherapie, 3rd edn. Springer, Berlin Heidelberg New York, pp 299–317
Bush RS (1986) The significance of anaemia in clinical radiotherapy. Int J Radiat Oncol Biol Phys 12: 2047–2050
Bush RS, Jenkin RDT, Alit WEC, Beale FA, Bean H, Dembo AJ, Pringle JF (1978) Definitive evidence for hypoxic cells influencing cure in cancer patients. Br J Cancer 37 [Suppl III]: 302–306
Dische S (1991) Radiotherapy and anaemia: the clinical experience. Radiother Oncol 20 [Suppl]: 35–40
Gray LH, Conger AD, Ebert M, Hornsey S, Scott OCA (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638–648
Hirst DG (1986) Anemia: a problem or an opportunity in radiotherapy? Int J Radiat Oncol Biol Phys 12: 2009–2017
Holthusen H (1936) Erfahrungen über die Verträglichkeitsgrenze für Röntgenstrahlen and deren Nutzanwendung zur Verhütung von Schäden. Strahlentherapie 57: 254–269
Moulder JE, Rockwell S (1984) Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10: 695–712
Overgaard J, Sand-Hansen H, Jorgensen K, Hjelm-Hansen M (1986) Primary radiotherapy of larynx and pharynx carcinoma: an analysis of some factors influencing local control and survival. Int J Radiat Oncol Biol Phys 12: 515–521
Overgaard J, Hjelm-Hansen M, Vendelbo-Johansen L, Andersen AP (1988) Comparison of conventional and split-course radiotherapy as primary treatment in carcinoma of the larynx. Acta Oncol 27: 147–152
Peters LJ, Withers HR, Thames HD, Fletcher GH (1982) Keynote address. The problem: tumor radioresistance in clinical radiotherapy. Int J Radiat Oncol Biol Phys 8: 101–108
Rubin P, Casarett GW (1968) Clinical radiation pathology. Saunders, Philadelphia Rugg T, Saunders M, Dische S (1990) Smoking and mucosal reactions to radiotherapy. Br J Radiol 63: 554–556
Suit HD, Walker AM (1988) Predictors of radiation response in use today: criteria for new assays and methods of verification. In: Chapman JD, Peters LJ, Withers HR (eds) Prediction of tumor treatment response. Pergamon, New York, pp 3–19
Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449–6465
Würschmidt F, Beck-Bornholdt HP, Vogler H, Jung H (1991) Radiotherapy of the rhabdomyosarcoma R1H of the rat: split course versus continuous fractionation. Strahlenther Onkol 167: 26–30
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Hübener, KH., Baumann, M., Krüll, A., Schwarz, R. (1993). Clinically Important Factors Modifying the Response of Tumors and Normal Tissue to Radiation Therapy. In: Hinkelbein, W., Bruggmoser, G., Frommhold, H., Wannenmacher, M. (eds) Acute and Long-Term Side-Effects of Radiotherapy. Recent Results in Cancer Research, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84892-6_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-84892-6_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84894-0
Online ISBN: 978-3-642-84892-6
eBook Packages: Springer Book Archive