Irradiation-Induced Brain Dysfunction in Children

  • R. Korinthenberg
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 130)


Radiotherapy of the brain and its surrounding tissues contributes significantly to the improvement in long-term event-free survival of children suffering from brain tumors or leukemia. With the prolonged life span the aspects of quality of life and treatment-related sequelae with possible damage to the central nervous system (CNS) are gaining greater importance.


Brain Tumor Acute Lymphoblastic Leukemia Prophylactic Cranial Irradiation Central Nervous System Relapse Childhood Acute Lymphoblastic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Appleton RE, Farrell K, Zaide J, Rogers P (1990) Decline in head growth and cognitive impairment in survivors of acute lymphoblastic leukaemia. Arch Dis Child 65: 530–534PubMedCrossRefGoogle Scholar
  2. Bleyer WA (1981) Neurologic sequelae of methotrexate and ionizing radiation: a new classification. Cancer Treat Rep 65 [Suppl 1]: 89–98PubMedGoogle Scholar
  3. Boller O, Kraus E, Rautenberg M (1990) Das Apathie-Syndrom als Folge einer postoperativen Bestrahlung bei kindlichen Hirntumoren. Neurochirurgia 33 [Suppl 11: 33–35Google Scholar
  4. Bordeaux JD, Dowell RE Jr, Copeland DR, Fletcher JM, Francis DJ, van Eys J (1988) A prospective study of neuropsychological sequelae in children with brain tumors. J Child Neurol 3: 63–68PubMedGoogle Scholar
  5. Brecher ML, Berger P, Freeman AI, Krischer J, Boyett J, Glicksman AS, Foreman E, Harris M, Jones B, Cohen M, Duffner PK, Rowland JH, Huang YP, Batnitzky S (1985) Computerized tomography scan findings in children with acute lymphocytic leukemia treated with three different methods of central nervous system prophylaxis. Cancer 56: 2430–2433PubMedCrossRefGoogle Scholar
  6. Brouwers P, Poplack D (1990) Memory and learning sequelae in long-term survivors of acute lymphoblastic leukemia: association with attention deficits. Am J Pediatr Hematol Oncol 12: 174–181PubMedCrossRefGoogle Scholar
  7. Chessells JM, Cox TCS, Kendall B, Cavanagh NPC, Jannoun L, Richards S (1990) Neurotoxicity in lymphoblastic leukemia: comparison of oral and intramuscular methotrexate and two doses of radiation. Arch Dis Child 65: 416–422PubMedCrossRefGoogle Scholar
  8. Cousens P, Waters B, Said J, Stevens M (1988) Cognitive effects of cranial irradiation in leukemia: a survey and meta-analysis. J Child Psychol Psychiat 29: 839–852PubMedCrossRefGoogle Scholar
  9. Danoff BF, Cowchock S, Marquette C, Mulgren L, Kramer S (1982) Assessment of the long-term effects of primary radiation therapy for brain tumors in children. Cancer 49: 1580–1586PubMedCrossRefGoogle Scholar
  10. Duffner PK, Cohen ME, Parker MS (1988) Prospective intellectual testing in children with brain tumors. Ann Neurol 23: 575–579PubMedCrossRefGoogle Scholar
  11. Ellenberg L, McComb JG, Siegel SE, Stowe S (1987) Factors affecting intellectual outcome in pediatric brain tumor patients. Neurosurgery 21: 638–644PubMedCrossRefGoogle Scholar
  12. Freeman JE, Johnston PGB, Voke JM (1973) Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukemia. Br Med J 4: 523–525PubMedCrossRefGoogle Scholar
  13. Harten G, Stephani U, Henze G, Langermann HJ, Riehm H, Hanefeld F (1984) Slight impairment of psychomotor skills in children after treatment of acute lymphoblastic leukemia. Eur J Pediatr 142: 189–197PubMedCrossRefGoogle Scholar
  14. Hirsch JF, Renier D, Czernichow P, Benveniste L, Pierre-Kahn A (1979) Medulloblastoma in childhood: survival and functional results. Acta Neurochir (wien) 48: 1–15CrossRefGoogle Scholar
  15. Holldack J, Kalif R, Schindler H, Rappen U, Havers W (1985) Neurologische and psychosoziale Störungen bei Kindern mit Hirntumoren. Klin Padiatr 197: 188–191PubMedCrossRefGoogle Scholar
  16. Korinthenberg R (1986) Leukämie and Nervensystem. Das Hirnstrombild im Erkrankungsund Behandlungsverlauf der akuten Leukämien des Kindesalters. Thieme, StuttgartGoogle Scholar
  17. Korinthenberg R, Igel B (1990) Prospective neurophysiological study in children treated for acute lymphoblastic leukaemia: serial EEG during treatment and long-term follow up with evoked potentials. Eur J Pediatr 15: 127–131CrossRefGoogle Scholar
  18. Korinthenberg R, Ullrich K, Ritter J, Stephani U (1990) Electrolytes, amino acids and proteins in lumbar CSF during the treatment of acute leukemia in childhood. Acta Paediatr Scand 79: 335–342PubMedCrossRefGoogle Scholar
  19. Lebaron S, Zeltzer PM, Zeltzer LK, Scott SE, Marlin AE (1988) Assessment of quality of survival in children with medulloblastoma and cerebellar astrocytoma. Cancer 62: 1215–1222PubMedCrossRefGoogle Scholar
  20. Longeway K, Mulhern, R, Crisco J, Kun L, Lauer S, Casper J, Camitta B, Hoffman RG (1990) Treatment of meningeal relapse in childhood acute lymphoblastic leukemia. II. A prospective study of intellectual loss specific to CNS relapse and therapy. Am J Pediatr Hematol Oncol 12: 45–50Google Scholar
  21. Marks JE, Baglan RJ, Prassad SC, Blank WF (1981) Cerebral radionecrosis: incidence and risk in relation to dose, time, fractionation and volume. Int J Radiat Oncol Biol Phys 7: 243–252PubMedCrossRefGoogle Scholar
  22. Mulhern RK, Wasserman AL, Fairclough D, Ochs J (1988) Memory function in disease-free survivors of childhood acute lymphocytic leukemia given CNS prophylaxis with or without 1800 cGy cranial irradiation. J Clin Oncol 6: 315–320PubMedGoogle Scholar
  23. Ochs JJ (1989) Neurotoxicity due to central nervous system therapy for childhood leukemia. Am J Pediatr Hematol Oncol 11: 93–105PubMedCrossRefGoogle Scholar
  24. Packer PJ, Zimmerman RA, Bilaniuk LT (1986) Magnetic resonance imaging in the evaluation of treatment-related central nervous system damage. Cancer 58: 635–640PubMedCrossRefGoogle Scholar
  25. Packer RJ, Sposto R, Atkins TE, Sutton LN, Bruce DA, Siegel KR, Rorke LB, Littman PA, Schut L (1987) Quality of life in children with primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Pediatr Neurosci 13: 169–175PubMedCrossRefGoogle Scholar
  26. Pearson ADJ, Campbell AN, McAllister VL, Pearson GL (1983) Intracranial calcification in survivors of childhood medulloblastoma. Arch Dis Child 58: 133136Google Scholar
  27. 28.
    Peckham VC, Meadows AT, Bartel N, Marrero 0 (1988) Educational late effects in long-term survivors of childhood acute lymphocytic leukemia. Pediatrics 81: 127133Google Scholar
  28. Riva D, Milani N, Pantaleoni C, Ballerini E, Giorgi (1991) Combined treatment modality for medulloblastoma in childhood: effects on neuropsychological functioning. Neuropediatrics 22: 36–42Google Scholar
  29. Rowland JH, Glidewell OJ, Sibley RF, Holland JC, Tull R, Berman A, Brecher ML, Harris M, Glicksman AS, Forman E, Jones B, Cohen ME, Duffner PK, Freeman AI (1984) Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia. Clin Oncol 2: 1327–1335Google Scholar
  30. Rubenstein CL, Varni JW, Katz ER (1990) Cognitive functioning in long-term survivors of childhood leukemia: a prospective analysis. J Dev Behav Pediatr 11: 301–305PubMedCrossRefGoogle Scholar
  31. Russo A, Tomarchio S, Pero G, Consoli G, Marina R, Rizzarai C, Schiliro G (1985) Abnormal visual-evoked potentials in leukemic children after cranial radiation. Med Pediatr Oncol 13: 313–317PubMedCrossRefGoogle Scholar
  32. Said JA, Waters BGH, Cousens P, Stevens MM (1989) Neuropsychological sequelae of central nervous system prophylaxis in survivors of childhood acute lymphoblastic leukemia. J Consult Clin Psychol 57: 251–256PubMedCrossRefGoogle Scholar
  33. Schlieper AE, Esseltine DW, Tarshis E (1989) Cognitive function in long survivors of childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 6: 1–9PubMedCrossRefGoogle Scholar
  34. Schuler D, Bakos M, Borsi J, Gacsaly I, Kamanchey R, Kardos G, Koos R, Nagy Cs. Revesz T, Somlo P, Gebauer E (1990) Neuropsychologic and CT examinations in leukemic patients surviving 10 or more years. Med Pediatr Oncol 18:123–125PubMedCrossRefGoogle Scholar
  35. Verity CM, Morgan H, Mott M, Oakhill A (1990) Do visual evoked potentials detect neural damage in children treated for cancer? Dev Med Child Neurol 32: 481–492PubMedCrossRefGoogle Scholar
  36. Volpe JJ (1987) Neurology of the newborn, 2nd edn. Saunders, PhiladelphiaGoogle Scholar
  37. Waber DP, Urion DK, Tarbell NJ, Niemeyer C, Gelber R, Sallan SE (1990) Late effects of central nervous system treatment of acute lymphoblastic leukemia in childhood are sex-dependent. Dev Med Child Neurol 32: 238–248PubMedCrossRefGoogle Scholar
  38. Zarbock G, Matthes-Martin S, Schulte FJ (1989) Lebensqualität and Restschadenssymptomatik bei Kleinhirntumoren im Kindes-and Jugendalter. Klin Padiatr 201: 337–345PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • R. Korinthenberg
    • 1
  1. 1.Abteilung Neuropädiatrie und MuskelerkrankungenUniversitätskinderklinikFreiburgFed. Rep. of Germany

Personalised recommendations