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Palliative Radiation in Metastatic Osteosarcoma

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Practical Approaches to Cancer Invasion and Metastases

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The patient is an 18-year-old black woman presenting with osteosarcoma arising in the distal femur and metastasizing to the lungs. Multidrug chemotherapy with methotrexate, ifosfamide, and cisplatin for 5 months resulted in an initially good response, although doxorubicin (Adriamycin) had to be discontinued because of cardiac arrhythmia. A wide resection with knee joint replacement was accomplished but there was rather rapid recurrence, both locally in the femur and the lung. The patient had an above-the-knee amputation for the local recurrence and was started on ifosfamide for the pulmonary metastases. During the next 6 months the patient developed left leg paresis and urinary retention associated with an intramedullary metastasis at T11–12. Further data is not provided regarding the response of the pulmonary metastases to ifosfamide, but on physical examination the patient was noted to be cachectic and on nasal oxygen.

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Author information

Authors and Affiliations

  1. Lawrence Berkeley Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA

    Joseph R. Castro MD (Director of Radiation Oncology)

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  1. Joseph R. Castro MD
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Editors and Affiliations

  1. Department of Radiation Oncology, Southern California Permanente Medical Group, 4950 Sunset Boulevard 2C, Los Angeles, CA, 90027, USA

    A. Robert Kagan MD

  2. Center for Health Sciences, Johnsson Cancer Center, University of California, Los Angeles, 10833 LeConte, Los Angeles, CA, 90024, USA

    Richard J. Steckel MD

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© 1994 Springer-Verlag Berlin Heidelberg

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Castro, J.R. (1994). Palliative Radiation in Metastatic Osteosarcoma. In: Kagan, A.R., Steckel, R.J. (eds) Practical Approaches to Cancer Invasion and Metastases. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84885-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-84885-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84887-2

  • Online ISBN: 978-3-642-84885-8

  • eBook Packages: Springer Book Archive

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