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Human Papillomaviruses and Cancer

  • D. R. Lowy
  • S. A. Sedman
  • B. D. Cohen
  • J. T. Schiller
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 128)

Abstract

Human papillomavirus (HPV) infection has been associated with specific human cancers, including cancer of the cervix and other genital cancers and skin cancers in patients with epidermodysplasia verruciformis. HPV does not thus far appear to be commonly associated with nongenital Bowen’s disease or nongenital skin cancers, although it is found routinely in genital forms of these conditions. Other factors in addition to HPV infection appear to contribute to tumor associated with HPV, which suggests that cellular changes in addition to HPV infection may be required for frank malignancy. Only a subset of the more than 60 HPV types have been found regularly in malignancies. Among the HPVs that infect the genital tract, some, such as HPV6 and HPV11, are only rarely detected in association with genital cancers, while others, including HPV16 and HPV18, are regularly found in malignancies. The former HPV types are therefore designated “low-risk” and the latter “high-risk.”

Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • D. R. Lowy
    • 1
  • S. A. Sedman
    • 1
  • B. D. Cohen
    • 1
  • J. T. Schiller
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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