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In Vitro Transformation and Tumor Progression

  • Conference paper
Skin Carcinogenesis in Man and in Experimental Models

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 128))

Abstract

In recent years, our understanding of the genetic basis of cancer has been greatly enhanced by the discovery of molecular elements involved in cell transformation such as the oncogenes, capable of neoplastically transforming certain rodent cells via DNA transfection (Land et al. 1983), and tumor suppressor genes. The latter were originally discovered by somatic cell-hybridization experiments via whole cell fusion revealing that the cancerous phenotype could be suppressed by the introduction of normal genetic information (Harris et al. 1969; Stanbridge 1976). Meanwhile, more than 50 types of oncogenes are known and an increasing number of “tumor suppressor genes” are being detected and cloned (for reviews see Stanbridge 1990; Bishop 1991).

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Author information

Authors and Affiliations

  1. Division of Carcinogenesis and Differentiation, German Cancer Research Center (DKFZ), W-6900, Heidelberg, Fed. Rep. of Germany

    P. Boukamp, D. Breitkreutz, A. Hülsen, S. Altmeyer, P. Tomakidi & N. E. Fusenig

Authors
  1. P. Boukamp
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  2. D. Breitkreutz
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  3. A. Hülsen
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  4. S. Altmeyer
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  5. P. Tomakidi
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  6. N. E. Fusenig
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Editor information

Editors and Affiliations

  1. Division: Mechanisms of Tumorigenesis, Research Program 3: Risk Factors of Cancer and Cancer Prevention, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    Erich Hecker

  2. Department of Dermatology, Mannheim Medical School, University of Heidelberg, Postfach 10 80 23, Theodor-Kutzer-Ufer, W-6800, Mannheim, Germany

    E. G. Jung (Director) (Director)

  3. Division: Biochemistry of Tissue Specific Regulation, Research Program 2: Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    F. Marks

  4. Department of Dermatology, University of Heidelberg, Voss-Str. 2, W-6900, Heidelberg, Germany

    W. Tilgen

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© 1993 Springer-Verlag Berlin · Heidelberg

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Boukamp, P., Breitkreutz, D., Hülsen, A., Altmeyer, S., Tomakidi, P., Fusenig, N.E. (1993). In Vitro Transformation and Tumor Progression. In: Hecker, E., Jung, E.G., Marks, F., Tilgen, W. (eds) Skin Carcinogenesis in Man and in Experimental Models. Recent Results in Cancer Research, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84881-0_25

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  • DOI: https://doi.org/10.1007/978-3-642-84881-0_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84883-4

  • Online ISBN: 978-3-642-84881-0

  • eBook Packages: Springer Book Archive

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