Ultraviolet Carcinogenesis: Environmental Effects of Ozone Depletion
Ultraviolet (UV) radiation is a useful agent in the study of skin carcinogenesis. The radiation administered in experiments may be selected for spectral composition and measured accurately (Forbes et al. 1982). The doses of UV radiation given to experimental animals may be in the same range as those received by people in daily life. The tumors induced appear on the skin and are accessible to observation from an early stage. In hairless mice, the tumors caused by UV radiation are predominantly squamous cell carcinomas, which are also found in human skin after prolonged sun exposure. Experimental studies make it possible to investigate the influence of wavelength, dose (de Gruijl et al. 1983), dose rate, etc. The wavelength-dependence, or “action spectrum,” is becoming known to a better approximation step by step. It extends throughout the entire UV wavelength range, with wavelengths differing in effectiveness by up to 4 orders of magnitude (de Gruijl and van der Leun 1992). The dose-effect relationship found in experiments with mice is basically of the same type as found in human epidemiology.
KeywordsOzone Depletion Total Ozone United Nations Environmental Programme Tropospheric Ozone Hairless Mouse
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