Abstract
The mouse skin models of chemical carcinogenesis have been extensively used to investigate the conversion of benign skin tumors (papillomas) to malignant squamous cell carcinomas (SCC). Less intense has been the use of these models for the study of tumor progression, which, as defined by Foulds (1975), does not necessarily include the conversion of benign into malignant tumors, but is a concept generally applied to define the gradual and sequential changes that take place in malignant tumors and that result in progressively more and more aggressive and life-threatening neoplasms. Although not fully exploited, the models of mouse skin carcinogenesis not only offer a very suitable in vivo system to study the biology of premalignant lesions and their possible transformation into completely malignant tumors, but also provide a gamut of malignant tumors of different biological potential that span from the nonmetastatic, slow-growing, well-differentiated SCC to the highly metastasizing, fast growing, poorly differentiated carcinomas that constitute an unusually relevant in vivo model of tumor progression (Klein-Szanto 1989).
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References
Aldaz CM, Conti CJ (1989) The premalignant nature of mouse skin papillomas. Histopathological, cytogenetic and biochemical evidence. In: Conti C, Slaga T, Klein-Szanto AJP (eds) Carcinogenesis — a comprehensive survey, vol II. Skin tumors: experimental and clinical aspects. Raven, New York, pp 227–240
Aldaz CM, Conti CJ, Klein-Szanto AJP et al. (1987) Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci USA 84: 2029–2032
Aldaz CM, Conti CJ, Larcher F, Trono D, Roop DR, Chesner J, Whitehead T, Slaga TJ (1988) Sequential development of aneuploidy, keratin modifications, and y-glutamyltransferase expression in mouse skin papillomas. Cancer Res 48: 3253–3257
Aldaz CM, Trono D, Larcher F, Slaga TJ, Conti CJ (1989) Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol Carcinog 2: 22–26
Aldaz CM, Conti CJ, Chen A, Bianchi A, Walker SB, DiGiovanni J (1991) Promoter independence as a feature of most skin papillomas in SENCAR mice. Cancer Res 51: 1045–1050
Ben-David Y, Bernstein A (1991) Friend virus-induced erythroleukemia and the multistage nature of cancer. Cell 66: 831–834
Bianchi AB, Aldaz CM, Conti CJ (1990) Non-random duplication of the chromosome 7 bearing a mutated Ha-ras-1 allele in mouse skin tumors. Proc Natl Acad Sci USA 87: 6902–6906
Bianchi AB, Navone NM, Aldaz CM, Conti CJ (1991) Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis. Proc Natl Acad Sci USA 88: 7590–7594
Bizub D, Wood AW, Skalka AM (1986) Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc Natl Acad Sci USA 83: 6048–6052
Bremmer R, Balmain A (1990) Genetic changes in skin tumour progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61: 407–417
Broders AC (1932) Practical points on the microscopic grading of carcinoma. NY J Med 32: 667–684
Brown K, Quintanilla M, Ramsden M, Kerr IB, Young S, Balmain A (1986) V-ras genes from Harvey and Balb murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis. Cell 46: 447–456
Buchmann A, Ruggeri B, Klein-Szanto AJP, Balmain A (1991) Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res 51: 4097–4101
Burns FJ, Albert RE, Altschuler B (1984) Cancer progression in mouse skin. In: Slaga TJ (ed) Mechanisms of tumor promotion: II. Tumor promotion and skin carcinogenesis. CRC Press, Boca Raton, pp 17–40
Chiba M, Maley MA, Klein-Szanto AJP (1986) Sequential study of GGT during complete and two stage skin carcinogenesis. Cancer Res 46: 259–263
Chiba M, Aldaz CM, Conti CJ, Klein-Szanto AJP (1991) Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis. Invasion Metastasis 11: 287–296
Conti CJ, Aldaz CM, O’Connell J, Klein-Szanto AJP, Slaga TJ (1986) Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis 7: 1845–1848
Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759–767
Fischer SM, O’Connell JF, Conti CJ, Tacker K, Fries JW, Patrick K, Adams LM, Slaga TJ (1987) Characterization of an inbred strain of the SENCAR mouse that is highly sensitive to phorbol esters. Carcinogenesis 8: 421–424
Foulds L (1975) Neoplasia of the skin. In: Foulds L (ed) Neoplastic development, vol 2. Academic, London, pp 17–107
Gimenez-Conti CI, Aldaz CM, Bianchi AB, Roop DR, Slaga TJ, Conti CJ (1990) Early expression of type I K13 in the progression of mouse skin papillomas. Carcinogenesis 11: 1995–1999
Klein-Szanto AJP (1989) Pathology of human and experimental skin tumors. In: Conti CJ, Slaga TJ, Klein-Szanto A (eds) Skin tumors: experimental and clinical aspects. Raven, New York, pp 19–53
Klein-Szanto AJP, Nelson KG, Shah Y, Slaga TJ (1983) Simultaneous appearance of keratin modification and y-glutamyltransferase activity as indicators of tumor progression in mouse skin papillomas. J Natl Cancer Inst 70: 161–168
Klein-Szanto AJP, Larcher F, Bonfil RD, Conti CJ (1989) Multistage carcinogenesis protocols produce spindle cell carcinomas in the mouse skin. Carcinogenesis 10: 2169–2172
Matrisian LM, Bowden GT, Krieg P, Furstenberger G, Briand J-P, Leroy P, Breathnach R (1986) An mRNA coding for the secreted protease transin is expressed more abundantly in malignant than benign tumors. Proc Natl Acad Sci USA 83: 9413–9417
Nischt R, Roop DR, Mehrel T, Yuspa SH, Rentrop M, Winter H, Schweizer J (1988) Aberrant expression during two-stage mouse skin carcinogenesis of a type 147-kDA keratin K13, normally associated with terminal differentiation. Mol Carcinog 1: 96–108
Quintanilla M, Brown K, Ramsden M, Balmain A (1986) Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322: 78–80
Reddy AL, Caldwell M, Fialkow PJ (1987) Studies of skin carcinogenesis in PGK mice: many promoter-independent papillomas and carcinomas do not develop from pre-existing promoter-dependent papillomas. Int J Cancer 39: 261–265
Roop DR, Kreig TM, Mehrel T, Cheng CK, Yuspa SH (1988) Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis. Cancer Res 48: 3245–3252
Ruggeri BR, Caamano J, Goodrow T, DiRado M, Bianchi A, Trono D, Conti CJ, Klein-Szanto AJP (1991) Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res 51: 6615–6621
Stenback F (1980) Characteristics of neoplastic progression and tumor behavior in skin carcinogenesis by different methods. Oncology 37: 163–168
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© 1993 Springer-Verlag Berlin · Heidelberg
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Klein-Szanto, A.J.P., Ruggeri, B., Bianchi, A., Conti, C.J. (1993). Cellular and Molecular Changes During Mouse Skin Tumor Progression. In: Hecker, E., Jung, E.G., Marks, F., Tilgen, W. (eds) Skin Carcinogenesis in Man and in Experimental Models. Recent Results in Cancer Research, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84881-0_14
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DOI: https://doi.org/10.1007/978-3-642-84881-0_14
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