Abstract
As early as the fifties it was apparent that human lipid and lipoprotein patterns showed a marked variation with gender and age (Gofman et al. 1950, Nikkila 1953, Russ et al. 1951). Attention was drawn to the role of sex steroids in the physiology of lipid and lipoprotein metabolism. Thereafter, it was hypothesized that female sex hormones exert a protective influence on the development of coronary heart disease. Epidemiological surveys such as the Framingham study clearly demonstrated that women of reproductive age experience significantly fewer clinical events due to atherosclerosis as compared to male individuals of the same age. The advantage in coronary morbidity and mortality completely disappears in postmenopausal patients.
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Teichmann, A.T. (1993). Pharmacology of Female Sex Hormones with Respect to Lipid and Lipoprotein Metabolism. In: Steinmetz, A., Schneider, J., Kaffarnik, H. (eds) Hormones in Lipoprotein Metabolism. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84855-1_9
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DOI: https://doi.org/10.1007/978-3-642-84855-1_9
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