Cholesterol Lowering Effect of Simvastatin in Patients with Normal and Impaired Renal Function
The cholesterol lowering effect of simvastatin was studied in hyperlipidaemic patients with normal and impaired renal function. 10 patients (group A, 4 male/6 female, aged 57 ± 8 years, serum creatinine 0.95 ± 0.10 mg/dl) and 10 patients with chronic interstitial nephritis (group B, 4 male, 6 female, aged 64 ± 6 years, serum creatinine 2.13 ± 0.65 mg/dl) were treated with simvastatin for a period of 12 weeks after a placebo period of 4 weeks. Total cholesterol was reduced from 308 ± 25 to 222 ± 31 mg/dl in group A and from 277 ± 28 to 204 ±28 mg/dl in group B. Mean final dose of simvastatin was 34 and 31 mg/d respectively. This reduction was seen only in the LDL fraction of cholesterol: in group A from 209 ± 44 mg/dl to 140 ± 30 and in group B from 185 ± 21 to 104 ± 37 mg/dl. HDL cholesterol was unaffected by simvastatin treatment.
In summary, simvastatin effectively lowers total and LDL-cholesterol in patients with normal renal function and in patients with mild chronic renal failure.
KeywordsPlacebo Cholesterol Filtration Europe Creatinine
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