Skip to main content

The Role and Mechanism of Glucocorticoids on the Modulation of Lipid and Lipoprotein Metabolism

  • Conference paper
Hormones in Lipoprotein Metabolism

Part of the book series: Recent Developments in Lipid and Lipoprotein Research ((LIPID))

Abstract

Glucocorticoid hormones have significant effects on the metabolism of lipids and lipoproteins. This review will briefly summarize the mechanism of action of glucocorticoid hormones, and then will describe some of the abnormalities in lipid and lipoprotein metabolism secondary to alterations in glucocorticoid levels that result in altered circulating concentrations of lipids and lipoproteins.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Muller M, Renkawitz R (1991) The glucocorticoid receptor. Biochim. et Biophys. Acta 1088: 171–182.

    CAS  Google Scholar 

  2. Marco J, Calle C, Hedo JA, Villanueva ML (1976) Enhanced glucagon secretion by pancreatic islets from prednisolone-treated mice. Diabetologia 12: 307–311.

    Article  PubMed  CAS  Google Scholar 

  3. Eigler N, Sacca L, Sherwin RS (1979) Synergistic interactions of physiologic increments of glucagon, epinephrine, and Cortisol in the dog. J Clin Invest 63: 114–123.

    Article  PubMed  CAS  Google Scholar 

  4. Rizza RA, Mandarino LJ, Gerich JE (1982) Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endo Metab 54: 131–138.

    Article  CAS  Google Scholar 

  5. Taskinen M-R, Nikkila EA, Pelkonen R, Sane T (1983) Plasma lipoproteins, lipolytic enzymes, and very low density lipoprotein triglyceride turnover in Cushing’s syndrome. J Clin Endo Metab 57: 619–626.

    Article  CAS  Google Scholar 

  6. Bagdade JD, Porte D, Bierman EL (1970) Steroid-induced lipemia. Arch Intern Med 125: 129–134.

    Article  PubMed  CAS  Google Scholar 

  7. Divakaran P, Friedmann N (1976) A fast in vitro effect of glucocorticoids on hepatic lipolysis. Endocrinology 98: 1550–1553.

    Article  PubMed  CAS  Google Scholar 

  8. Krotkiewski M, Bjorntorp P (1975) The effects of dexamethasone and starvation on body composition and regional adipose tissue cellularity in the rat. Acta Endocrinologica 80: 667–675.

    PubMed  CAS  Google Scholar 

  9. Cole TG, Wilcox HG, Heimberg M (1982) Effects of adrenalectomy and dexamethasone on hepatic lipid metabolism. J Lipid Res 23: 81–91.

    PubMed  CAS  Google Scholar 

  10. Henze K, Chait A, Albers JJ, Bierman EL (1983) Hydrocortisone decreases the internalization of low density lipoprotein in cultred human fibroblasts and arterial smooth muscle cells. European J Clin Invest 13: 171–177.

    Article  CAS  Google Scholar 

  11. Brindley DN (1981) Regulation of hepatic triacylglycerol synthesis and lipoprotein metabolism by glucocorticoids. Clinical Science 61: 129–133.

    PubMed  CAS  Google Scholar 

  12. Mangiapane EH, Brindley DN (1986) Effects of dexamethasone and insulin on the synthesis of triacylglycerols and phosphatidylcholine and the secretion of very low-density lipoproteins and lysophosphatidylcholine by monolayer cultures of rat hepatocytes. Biochem J 233: 151–160.

    PubMed  CAS  Google Scholar 

  13. Bartlett SM, Gibbons GF (1988) Short- and longer-term regulation of very-low density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes. Biochem J 249: 37–43.

    PubMed  CAS  Google Scholar 

  14. Tobey TA, Greenfield M, Kraemer F, Reaven GM (1981) Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man. Metabolism 30: 165–171.

    Article  PubMed  CAS  Google Scholar 

  15. Howard BV (1987) Lipoprotien metabolism in diabetes mellitus. J Lipid Res 28; 613–628.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gregg, R.E. (1993). The Role and Mechanism of Glucocorticoids on the Modulation of Lipid and Lipoprotein Metabolism. In: Steinmetz, A., Schneider, J., Kaffarnik, H. (eds) Hormones in Lipoprotein Metabolism. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84855-1_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84855-1_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55995-5

  • Online ISBN: 978-3-642-84855-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics