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Effects of a New Oral Contraceptive Containing Ethinyl Estradiol and Desogestrel on Plasma Lipoproteins and Apolipoproteins

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Hormones in Lipoprotein Metabolism

Part of the book series: Recent Developments in Lipid and Lipoprotein Research ((LIPID))

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Summary

The effect of a new two phase oral contraceptive containing ethinyl estradiol (EE) and desogestrel (DG) (40 μg EE + 24 μg DG for 7 days, and 30 μg EE +125 μg DG) on plasma lipoproteins and apolipoproteins has been studied in 19 healthy women. After an initial control cycle, the EE/DG combination was administered for six months, aijd the study was completed with a final washout cycle. The EE/DG combination lead to increases in total triglycerides, very low density lipoproteins, and high density lipoproteins. HDL3-cholesterol increased significantly, whereas HDL3-cholesterol was not affected. Apolipoproteins A-I, A-II, and B increased. While both cholesterol and triglyce-rides in intermediate density lipoproteins increased, there was a 20% decrease in apoE. Apolipoprotein (a) decreased by 9% and 24% after one and three months of treatment, respectively. It reverted to baseline levels in the sixth treatment cycle, and even increased in a final wash out cycle.

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Abbreviations

EE:

ethinyl estradiol

DG:

desogestrel

VLDL:

very low density lipoproteins

IDL:

intermediate density lipoproteins

LDL:

low density lipoproteins

HDL:

high density lipoproteins

C:

cholestetol

TG:

triglycerides

PL:

phospolipids

HTGL:

hepatic triglyceride lipase

OC:

oral contraceptive

apo:

apolipoprotein

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Authors
  1. W. März
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  2. C. Jung-Hoffmann
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  3. R. Siekmeier
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  4. H. Kuhl
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  5. W. Gross
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Editor information

Editors and Affiliations

  1. Zentrum für Innere Medizin, Abt. für Endokrinologie und Stoffwechsel, Klinikum der Philipps-Universität Marburg, Baldingerstraße, D-W-3550, Marburg, Germany

    Armin Steinmetz , Jürgen Schneider  & Hans Kaffarnik ,  & 

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© 1993 Springer-Verlag Berlin Heidelberg

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März, W., Jung-Hoffmann, C., Siekmeier, R., Kuhl, H., Gross, W. (1993). Effects of a New Oral Contraceptive Containing Ethinyl Estradiol and Desogestrel on Plasma Lipoproteins and Apolipoproteins. In: Steinmetz, A., Schneider, J., Kaffarnik, H. (eds) Hormones in Lipoprotein Metabolism. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84855-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-84855-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55995-5

  • Online ISBN: 978-3-642-84855-1

  • eBook Packages: Springer Book Archive

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