Summary
By usual clinical reasons 737 men and 280 women, mean age 59±10 years, were subjected in sequence to coronary angiography. We compared men and women concerning the relationship between their angiographic findings and lipoproteins as well as other risk factors.
In men and women with proven coronary artery disease (CAD) of same degree of severity we found different pattern of lipoproteins: Fe-male patients show higher levels of cholesterol (chol), low density lipoprotein chol (LDL-C) and high density lipoprotein chol (HDL-C) and lower ratios of chol/HDL-C and LDL-C/HDL-C . In women weight and age are higher, but they smoked less than men. Lipoprotein(a) [Lp(a)] levels are not different in men and women.
Discriminators of presence of CAD in female are 1st chol, 2nd; smoking, 3rd high Lp(a) levels and 4th diabetes mellitus; discriminators of early manifestation are 1st family history and 2nd smoking habits (discriminant analysis). In contrast to the findings in male, lipoprotein levels in young female with CAD are lower than in older female patients.
Differences could be caused by the considerable menopausal changes of lipoprotein pattern in women.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Campos H, McNamara JR, Wilson PWF, Ordovas JM, Schaefer EJ (1988) Differences in low density lipoprotein subfractions and apolipoproteins in premenopausal and postmenopausal women. J Clin Endocrinol Metab 67: 30–35.
Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH (1987) Menopause and the risk of coronary heart disease in women. N Engl J Med 316: 1105–10.
Gensini GG (1983) A more meaningful scoring system for determining the severi-ty of coronary heart disease. Am J Cardiol 51: 606
Jensen J, Riis BJ, Strom V, Nilas L, Christiansen C (1987) Long-term effects of percutaneous estrogens and oral progesterone on serum lipoproteins in postme-nopausal women. Am J Obstet Gynecol 156: 66–71.
Longcope C, Herbert PN, McKinlay S, Goldfield SRW (1990) The relationship of total and free estrogens and sex hormone-binding globulin with lipoproteins in women. J Clin Endocrinol Metab 71: 67–72.
Norusis MJ (1988) SPSS-X advanced statistics guide,2nd edition, New York,1988.
Sandkamp M,G (1990) Lipoprotein (a) in PROCAM participants and young myocardial infarction survivers. In: Scanu AM, ed. lipoprotein(a): 25 years of progress. New York: Academic Press, 205–209.
Stefanick ML, Williams PT, Krauss RM, Terry RB, Vranizan KM, Wood PD (1987) Relationships of plasma estradiol, testosterone, and sex hormone-binding globulin with lipoproteins, apolipoproteins, and high density lipoprotein subfractions in men. J Clin Endocrinol Metab 64: 723–729.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hahmann, H. et al. (1993). Different Lipoprotein Patterns in Men and Women Examined by Coronary Angiography. In: Steinmetz, A., Schneider, J., Kaffarnik, H. (eds) Hormones in Lipoprotein Metabolism. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84855-1_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-84855-1_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55995-5
Online ISBN: 978-3-642-84855-1
eBook Packages: Springer Book Archive