Summary
This chapter summarizes the evidence that cytomegalovirus is present in certain cells in whole blood in both the active and latent state and that the virus can be transmitted in its latent state to a susceptible host by transfusion. Normal and immunosuppressed adults and newborn infant recipients are discussed as well as some methods of prevention.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adler SP (1983) Transfusion-associated cytomegalovirus infections. Rev Infect Dis 5: 977–993
Adler SP, Chandrika T, Lawrence L, Baggett J (1983) Cytomegalovirus infections in neonates acquired by blood transfusions. Pediatr Infect Dis 2: 114–118
Adler SP, Baggett J, McVoy M (1985) Transfusion-associated cytomegalovirus infections in seropositive cardiac surgery patients. Lancet 2: 743–747
Armstrong D, Ely M, Steger L (1971) Post-transfusion cytomegaloviremia and persistence of cytomegalovirus in blood. Infect Immun 3: 159–163
Armstrong JA, Tarr GC, Youngblood LA et al. (1976) Cytomegalovirus infection in children undergoing open-heart surgery. Yale J Biol Med 49: 83–91
Ballard RA, Drew WL, Hufnagle KG et al. (1979) Acquired cytomegalovirus infection in preterm infants. Am J Dis Child 133: 442–448
Bayer WL (1977) The effect of frozen blood on the relationship of cytomegalovirus and hepatitis virus to infection and disease. In: Dawson RB, Barnes A Jr (eds) Clinical and practical aspects of the use of frozen blood. American Association of Blood Banks, Washington, pp 133–145
Betts RF (1982) Cytomegalovirus infection in transplant patients. Prog Med Virol 28: 44–64
Betts RF, Freeman RB, Douglas RG Jr, Talley TE, Rundell B (1975) Transmission of cytomegalovirus infection with renal allograft. Kidney Int 8: 385–392
Betts RF, Cestero RVM, Freeman RB, Douglas RC Jr (1979) Epidemiology of cytomegalovirus infection in end stage renal disease. J Med Virol 4: 89–96
Bowden RA, Sayers M, Flournoy N et al. (1986) Cytomegalovirus immune globulin and seronegative blood products to prevent primary cytomegalovirus infection after marrow transplantation. N Engl J Med 314: 1006–1010
Brady MT, Milam JD, Anderson DC et al. (1984) Use of deglycerolized red blood cells to prevent posttransfusion infection with cytomegalovirus in neonates. J Infect Dis 150: 334–339
Braun WE, Nankervis G, Banowsky LH, Protiva D, Biekert E, McHenry MC (1976) A prospective study of cytomegalovirus infections in 75 renal allograft recipients. Proc Clin Dial Transplant Forum 6: 8–12
Brautigam AR, Dutko FJ, Olding LB, Oldstone MBA (1979) Pathogenesis of murine cytomegalovirus infection: the macrophage as a permissive cell for cytomegalovirus infection, replication and latency. J Gen Virol 44: 349–359
Caul EO, Clarke SKR, Mott MG et al. (1971) Cytomegalovirus infections after open heart surgery. Lancet 1: 777–781
Chou S, Kim DY, Norman DJ (1987) Transmission of cytomegalovirus by pretransplant leukocyte transfusions in renal transplant candidates. J Infect Dis 155: 565–567
Chou SW, Norman DJ (1988) The influence of donor factors other than serologic status on transmission of cytomegalovirus to transplant recipients. Transplantation 46: 89–93
Condie RM, O’Reilly RJ (1984) Prevention of cytomegalovirus infection by prophylaxis with an intravenous, hyperimmune, native, unmodified cytomegalovirus globulin: randomized trial in bone marrow transplant recipients. Am J Med 76: 134–141
Diosi P, Moldovan E, Tomescu N (1969) Latent cytomegalovirus infection in blood donors. Br Med J 4: 660–662
Embil JA, Folkins DF, Haldane EV et al. (1968) Cytomegalovirus infection following extra-corporeal circulation in children: a prospective study. Lancet 2: 1151–1155
Fiala M, Chatterjee S (1982) The role of lymphocytes in infections due to Epstein-Barr virus and cytomegalovirus ( Letter ). J Infect Dis 146: 300–301
Foster KM, Jack I (1969) A prospective study of the role of cytomegalovirus in post-transfusion mononucleosis. N Engl J Med 280: 1311–1316
Gadler H, Tillegard A, Groth CG (1982) Studies of cytomegalovirus infection in renal allograft recipients. I. Virus isolation. Scand J Infect Dis 14: 81–87
Garnett HM (1982) Isolation of human cytomegalovirus from peripheral blood T cells of renal transplant patients. J Lab Clin Med 99: 92–97
Gentry LO, Zeluff BJ (1986) Diagnosis and treatment of infection in cardiac transplant patients. Surg Clin North Am 66: 459–465
Hamilton JD (1982) Cytomegalovirus and immunity, vol. 12. Karger, Basel
Harnden DG, Elsdale TR, Young DE, Ross A (1967) The isolation of cytomegalovirus from peripheral blood. Blood 30: 120–125
Henle W, Henle G, Scriba M et al. (1970) Antibody responses to the Epstein-Barr virus and cytomegalovirus after open-heart and other surgery. N Engl J Med 282: 1068–1074
Ho M (1982) Cytomegalovirus — biology and infection. Plenum, New York
Ho M, Suwansirikul S, Dowling JN, Youngblood LA, Armstrong JA (1975) The transplanted kidney as a source of cytomegalovirus infection. N Engl J Med 293: 1109–1112
Jackson JB, Orr HT, McCullough JJ, Jordan MC (1987) Failure to detect human cytomegalovirus DNA in IgM-seropositive blood donors by spot hybridization. J Infect Dis 156: 1013–1016
Jesionek A, Kiolemenoglou B (1904) Über einen Befund von protozoenartigen Gebilden in den Organen eines hereditär-luetischen Fötus. MMW 51: 1905–1907
Kaariainen L, Klemola E, Paloheimo J (1966) Rise of cytomegalovirus antibodies in an infectious-mononucleosis-like syndrome after transfusion. Br Med J 1: 1270–1272
Kaariainen L, Paloheimo J, Klemola E et al. (1966) Cytomegalovirus-mononucleosis: isolation of virus and demonstration of subclinical infections after blood transfusion in connection with open-heart surgery. Ann Med Exp Biol Fenn 44: 297–301
Klemola E, Kaariainen L (1965) Cytomegalovirus — a possible cause of a disease resembling infectious mononucleosis. Br Med J 2: 1099–1102
Klemola E, von Essen R, Paloheimo J, Furuhjelm U (1969) Cytomegalovirus antibodies in donors of fresh blood to patients submitted to open-heart surgery. Scand J Infect Dis 1: 137–140
Kumar A, Nankervis GA, Cooper AR et al. (1980) Acquisition of cytomegalovirus infection in infants following exchange transfusion: a prospective study. Transfusion 20: 327–331
Lamberson HV Jr, McMillian JA, Weiner LB et al. (1988) Prevention of transfusion-associated cytomegalovirus ( CMV) infection in neonates by screening blood donors for IgM to CMV. J Infect Dis 157: 820–823
Lang DJ, Hanshaw JB (1969) Cytomegalovirus infection and the postperfusion syndrome. N Engl J Med 280: 1145–1149
Lang DJ, Ebert PA, Rodgers BM, Boggess HP, Rixse RS (1977) Reduction of postperfusion cytomegalovirus-infections following the use of leukocyte depleted blood. Transfusion 17: 391–395
Lowenstein C (1907) Über protozoenartige Gebilde in den Organen von Kindern. Zentralbi Allg Pathol Pathol Anat 18: 513–518
Luban NL, Williams AE, MacDonald MG, Mikesell GT, Williams KM, Sacher RA (1987) Low incidence of acquired cytomegalovirus infection in neonates transfused with washed red blood cells. Am J Dis Child 141: 416–419
Luby JP, Burnett W, Hull AR, Ware AJ, Shorey JW, Peters PC (1974) Relationship between cytomegalovirus and hepatic function abnormalities in the period after renal transplant. J Infect Dis 129: 511–518
Luthardt T, Siebert H, Losel I et al. (1971) Cytomegalievirus-Infektionen bei Kindern mit Blutaustauschtransfusion im Neugeborenenalter. Klin Wochenschr 49: 81–86
Mackinnon S, Burnett AK, Crawford RJ, Cameron S, Leask BG, Sommerville RG (1988) Seronegative blood products prevent primary cytomegalovirus infection after bone marrow transplantation. J Clin Pathol 41: 948–950
Martin DC, Katzenstein DA, Yu GSM, Jordan MC (1984) Cytomegalovirus viremia detected by molecular hybridization and electron microscopy. Ann Intern Med 100: 222–225
McCordock HA, Smith MG (1936) The visceral lesions produced in mice by the salivary gland virus of mice. J Exp Med 63: 303–310
Medical Research Council (MRC) Working Party on Post-Transfusion (1974) Hepatitis report to the MRC Blood Transfusion Research Committee: Post-transfusion hepatitis in a London hospital: results of a two-year prospective study. J Hyg (Lond) 73: 173–188
Meyers JD, Leszczynski J, Zaia JA et al. (1983) Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation. Ann Intern Med 98: 442–446
Meyers JD, Flournoy N, Thomas ED (1986) Risk factors for cytomegalovirus infection after human marrow transplantation. J Infect Dis 153: 478–488
Monif GRG, Daicoff GI, Flory LL (1976) Blood as a potential vehicle for the cytomegaloviruses. Am J Obstet Gynecol 126: 445–448
Murphy MF, Grint PC, Hardiman AE, Lister TA, Waters AH (1988) Use of leucocyte-poor blood components to prevent primary cytomegalovirus (CMV) infection in patients with acute leukaemia ( Letter ). Br J Haematol 70: 253–254
Nankervis GA (1976) Cytomegalovirus infections in the blood recipient. Yale J Biol Med 49: 13–15
Paloheimo JA, von Essen R, Klemola E, Kaariainen L, Siltanen P (1968) Subclinical cytomegalovirus infections and cytomegalovirus mononucleosis after open heart surgery. Am J Cardiol 22: 624–630
Preiksaitis JK, Rosno S, Grumet C, Merigan TC (1983) Infections due to herpesviruses in cardiac transplant recipients: role of the donor heart and immunosuppressive therapy. J Infect Dis 147: 974–981
Preiksaitis JK, Grumet FC, Smith WK, Merigan TC (1985) Transfusion-acquired cytomegalovirus infection in cardiac surgery patients. J Med Virol 15: 283–290
Preiksaitis JK, Brown L, McKenzie M (1988) The risk of cytomegalovirus infection in seronegative transfusion recipients not receiving exogenenous immunosuppression. J Infect Dis 157: 523–529
Preiksaitis JK, Brown L, McKenzie M (1988) Transfusion-acquired cytomegalovirus infection in neonates. A prospective study. Transfusion 28: 205–209
Prince AM, Szmuness W, Millian SJ et al. (1971) A serologic study of cytomegalovirus infections associated with blood transfusions. N Engl J Med 284: 1125–1131
Quinnan GV Jr, Masur H, Rook AH et al. (1984) Herpesvirus infections in the acquired immune deficiency syndrome. JAMA 252: 72–77
Ribbert H (1904) Über protozoenartige Zellen in der Niere eines syphilitischen Neugeborenen and in der Parotis von Kindern. Zentralbl Allg Pathol Pathol Anat 15: 945–948
Rinaldo CRJ, Black PH, Hirsch MS (1977) Interaction of cytomegalovirus with leukocytes from patients with mononucleosis due to cytomegalovirus. J Infect Dis 136: 667678
Rowe WP, Hartley JW, Waterman S, Turner HE, Huebner RJ (1956) Cytopathogenic agent resembling human salivary gland virus recovered from tissue cultures of human adenoids. Proc Soc Exp Biol Med 92: 418–424
Rubin RH (1989) The indirect effects of cytomegalovirus infection on the outcome of organ transplantation. JAMA 261: 3607–3609
Rubin RH, Tolkoff-Rubin NE, Oliver D et al. (1985) Multicenter seroepidemiologic study of the impact of cytomegalovirus infection on renal transplantation. Transplantation 40: 243–249
Saltzman RL, Quirk MR, Jordan MC (1988) Disseminated cytomegalovirus infection. Molecular analysis of virus and leukocyte interactions in viremia. J Clin Invest 81: 75–81
Schrier RD, Nelson JA, Oldstone MBA (1985) Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science 230: 1048–1051
Singh N, Dummer JS, Kusne S et al. (1988) Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: transmission by donated organ and the effect of OKT3 antibodies. J Infect Dis 158: 124–131
Smith D Jr, Wright P, Estes W et al. (1983) Posttransfusion cytomegalovirus infection in neonates weighing less than 1250 grams ( Abstr ). Transfusion 23: 420
Smith MG (1954) Propagation of salivary gland virus of the mouse in tissue cultures. Proc Soc Exp Biol Med 86: 435–440
Smith MG (1956) Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SGV) disease. Proc Soc Exp Biol Med 92: 424–430
Spector SA, Schmidt K, Ticknor W et al. (1979) Cytomegaloviruria in older infants in intensive care nurseries. J Pediatr 95: 444–446
Spector SA, Rua JA, Spector DH, McMillan RM (1984) Detection of human cytomegalovirus in clinical specimens by DNA—DNA hybridization. J Infect Dis 150: 121126
Stagno S, Pass RF, Dworsky ME et al. (1982) Congenital cytomegalovirus infection: the relative importance of primary and recurrent maternal infection. N Engl J Med 306: 945949
Stanier P, Taylor DL, Kitchen AD, Wales N, Tryhorn Y, Tyms AS (1989) Persistence of cytomegalovirus in mononuclear cells in peripheral blood from blood donors. Br Med J 299: 897–898
Surgenor D, Wallace E, Hao S, Chapman R (1990) Collection and transfusion of blood in the United States, 1982–1988. N Engl J Med 322: 1646–1651
Taylor BJ, Jacobs RF, Baker RL, Moses EB, McSwain BE, Shulman G (1986) Frozen deglycerolyzed blood prevents transfusion-acquired cytomegalovirus infections in neonates. Pediatr Infect Dis 5: 188–191
Tegtmeier GE (1985) Cytomegalovirus and blood transfusion. In: Dodd RY, Barker LF (eds) Infection immunity and blood transfusion. Liss, New York, pp 175–199
Tegtmeier GE (1986) Transfusion-transmitted cytomegalovirus infections: significance and control. Vox Sang 51 Suppl 1: 22–30
Tegtmeier GE (1989) Posttransfusion cytomegalovirus infections. Arch Pathol Lab Med 113: 236–245
Tolkoff-Rubin NE, Rubin RH, Keller EE (1978) Cytomegalovirus infection in dialysis patients and personnel. Ann Intern Med 89: 625–628
Tolpin MD, Stewart JA, Warren D et al. (1985) Transfusion transmission of cytomegalovirus confirmed by restriction endonuclease analysis. J Pediatr 107: 953–956
Weller TH, Mccauley JC, Craig JM, Wirth P (1957) Isolation of intranuclear inclusion producing agents from infants with illnesses resembling cytomegalic inclusion disease. Proc Soc Exp Biol Med 94: 4–12
Wheeler EO, Turner JD, Scannell JG (1962) Fever, splenomegaly and atypical lymphocytes. N Engl J Med 266: 454–456
Wilhelm JA, Matter L, Schopfer K (1986) The risk of transmitting cytomegalovirus to patients receiving blood transfusions. J Infect Dis 154: 169–171
Winston DJ, Gale RP, Meyer DV, Young LS, Group UBMT (1979) Infectious complications of human bone marrow transplantation. Medicine (Baltimore) 58: 1–31
Winston DJ, Ho WG, Lin C, Budinger MD, Champlin RE, Gale RP (1984) Intravenous immunoglobulin for modification of cytomegalovirus infections associated with bone marrow transplantation. Am J Med 76: 128–133
Yeager AS (1974) Transfusion-acquired cytomegalovirus infection in newborn infants. Am J Dis Child 128: 478–483
Yeager AS, Grumet FC, Hafleigh EB, Arvin AM, Bradley JS, Prober CG (1981) Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr 98: 281–287
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hamilton, J.D. (1993). Cytomegalovirus and Blood Transfusion. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-84850-6_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84852-0
Online ISBN: 978-3-642-84850-6
eBook Packages: Springer Book Archive