Postscript: What Is the Role of Dendritic Cells in the Pathogenesis of Human Cytomegalovirus in Immunocompetent and Immunocompromised Hosts?

  • Yechiel Becker
Part of the Frontiers of Virology book series (FRVIROLOGY, volume 2)


The information concerning the complications that human cytomegalovirus (HCMV) is capable of inflicting in immunosuppressed people (organ transplant patients and acquired immune deficiency, AIDS, patients) is described in detail in numerous chapters of this book. Yet, the responses of immune cells in the protection against HMCV infections and the role of the dendritic cell system in the defense against virus reactivations is not fully known. From the research on the role of dendritic cells in the cellular defense against Herpes simplex virus-1, it is possible to suggest that further studies on the effect of immunosuppressive drugs (cyclosporin A, cyclophosphamide, FK506) and their inhibitory effect on dendritic cells may lead to differentiation between the antiviral dendritic cells and the dendritic cells involved in graft rejection. Drugs which do not prevent the antiviral activity of dendritic cells but preserve the dendritic cells capable of anti-HMCV activity, while inhibiting the dendritic cells involved in graft rejection, might be the immunosuppressive drugs of choice.


Dendritic Cell Immunosuppressive Drug Graft Rejection Renal Transplant Patient Human Cytomegalovirus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Yechiel Becker
    • 1
  1. 1.Department of Molecular Virology, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

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