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Transcription Factors and Viral Regulatory Proteins as Potential Mediators of Human Cytomegalovirus Pathogenesis

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Molecular Aspects of Human Cytomegalovirus Diseases

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 2))

Summary

The mechanism(s) of pathogenesis caused by persistent viruses such as the human cytomegalovirus (HCMV) are strongly associated with the control of transcription. In this chapter we explore in vitro systems which suggest the interplay of both viral and cellular regulatory factors as major determinants in controlling the expression state of HCMV. Importantly, we address the issue of both cellular transcription factors and viral regulatory proteins as possible mediators in the pathogenesis associated with HCMV infection.

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Authors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, Clinic, La Jolla, CA, 92037, USA

    Peter Ghazal & Jay A. Nelson

  2. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, Clinic, La Jolla, CA, 92037, USA

    Peter Ghazal

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  1. Peter Ghazal
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Editors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, 910010, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

  3. Lineberger Comprehensive Cancer Research Center, The University of North Carolina, CB # 7259, Rm. 117, Lineberger Building, 27599-7295, Chapel Hill, NC, USA

    Eng-Shang Huang Ph. D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Ghazal, P., Nelson, J.A. (1993). Transcription Factors and Viral Regulatory Proteins as Potential Mediators of Human Cytomegalovirus Pathogenesis. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-84850-6_18

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