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Immediate-Early Genes of Human Cytomegalovirus: Organization and Function

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Molecular Aspects of Human Cytomegalovirus Diseases

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 2))

Summary

Immediate-early (IE) genes of human cytomegalovirus are the first genes expressed after the virus infects the cell. The most extensively characterized of the IE genes is the major IE gene region. Originating from this gene is a series of overlapping mRNAs which encode proteins that have common and unique domains. Functionally, at least three IE proteins, IE 72, IE 55, and IE 86, are responsible for regulation of viral promoters. These proteins interact to enhance and repress expression of the major IE promoter resulting in a coordinate regulation that affects the balance of IE gene expression. In addition, IE proteins interact with cell factors during regulation of viral gene expression to activate early promoters. Therefore, the coordinate regulation of IE genes and their corresponding proteins, by cellular proteins in the infected cell, is likely to be the single most important determinant influencing the outcome of human cytomegalovirus infection.

This work was supported by Public Health Service Grant AI-23313 from the National Institutes of Health

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  1. Department of Microbiology and Immunology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA, 23501-1980, USA

    Richard M. Stenberg

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Editors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, 910010, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

  3. Lineberger Comprehensive Cancer Research Center, The University of North Carolina, CB # 7259, Rm. 117, Lineberger Building, 27599-7295, Chapel Hill, NC, USA

    Eng-Shang Huang Ph. D.

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Stenberg, R.M. (1993). Immediate-Early Genes of Human Cytomegalovirus: Organization and Function. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_17

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