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The Management of Cytomegalovirus Infection in Heart-Lung Transplant Recipients

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Molecular Aspects of Human Cytomegalovirus Diseases

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 2))

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Summary

In the 1980s heart-lung transplantation (HLT) [1, 2], evolved from an experimental and innovative stage to a clinical treatment. Despite improvements in survival and understanding of pathogenesis of the lung disease in HLT recipients, cytomegalovirus (CMV) infection remains an important cause of death and morbidity. Donor-acquired primary CMV disease may be effectively prevented by prospective donor and recipient matching. Considerable progress has been made in the diagnosis of CMV pneumonia by the use of trans-bronchial lung biopsy (TBB), and the antiviral drug ganciclovir provides effective treatment of reactivation or reinfection. However, the mechanisms and immunological response to CMV infection in this patient population remain poorly understood.

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Authors and Affiliations

  1. Heart-Lung Transplant Research Unit, Papworth Hospital, Cambridge, CB3 8RE, UK

    R. L. Smyth, T. W. Higenbottam, J. P. Scott & J. Wallwork

  2. Oncology Unit, Ward C3, Royal Liverpool Children’s Hospital, Alder Hey, Liverpool, L12 2AP, UK

    R. L. Smyth

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  1. R. L. Smyth
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  2. T. W. Higenbottam
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  3. J. P. Scott
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  4. J. Wallwork
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Editors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, 910010, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

  3. Lineberger Comprehensive Cancer Research Center, The University of North Carolina, CB # 7259, Rm. 117, Lineberger Building, 27599-7295, Chapel Hill, NC, USA

    Eng-Shang Huang Ph. D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Smyth, R.L., Higenbottam, T.W., Scott, J.P., Wallwork, J. (1993). The Management of Cytomegalovirus Infection in Heart-Lung Transplant Recipients. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-84850-6_12

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