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Leukocyte-Endothelial Interactions in Trauma and Sepsis

  • Chapter
Mediators of Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 16))

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Abstract

The development of organ failure may occur within the first days after trauma (early organ failure) or after one or two weeks (late organ failure) in ICU patients. The reaction that leads to organ damage and organ failure is a generalized inflammatory event [1]. This inflammation may be non-bacterial in the early stage of organ failure, and be aggravated by the influence of bacterial factors during the development of late organ failure. The non-bacterial inflammatory reaction is induced by the initial injury and is usually based on three factors: tissue ischemia/hypoxia, reperfusion events with generation of oxygen radicals; stimulation of phagocytes by complement split products or other humoral inflammatory factors; and the interaction with endothelial cells. This chapter focuses on PMN/endothelial activation with special emphasis on the PMN-endothelial interaction. The results of these events will be discussed in the trauma and the sepsis situation.

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Authors
  1. H. Redl
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  2. G. Schlag
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  3. I. Marzi
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Centre Hospitalier, Universitaire de Liège, B-35 Domaine Universitaire du Sart Tilman, 4000, Liège, Belgium

    Maurice Lamy

  2. Department of Intensive Care, Free University Hospital, De Boelelaan 1117, 1007, MS, Amsterdam, The Netherlands

    Lambert G. Thijs

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© 1992 Springer-Verlag Berlin Heidelberg

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Redl, H., Schlag, G., Marzi, I. (1992). Leukocyte-Endothelial Interactions in Trauma and Sepsis. In: Lamy, M., Thijs, L.G. (eds) Mediators of Sepsis. Update in Intensive Care and Emergency Medicine, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84827-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-84827-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84829-2

  • Online ISBN: 978-3-642-84827-8

  • eBook Packages: Springer Book Archive

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