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Experimental Basis of New Therapeutic Approaches to Septic Shock

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Mediators of Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 16))

Abstract

In 1982, the distinguished scientist, David Tyrrell, wrote a monograph entitled “ The Abolition of Infection: Hope or Illusion?” [1]. In it, he drew attention to the fact that the long-expected demise of infection as a “problem” was evidently not going to happen. Issues such as the development of antibiotic resistance in common bacteria, and the contribution of the host to the pathophysiological disease would, he said, require new and innovative approaches to the treatment of infection. The need for these new strategies was particularly apparent in the case of septic shock. Mortality was “stuck”, rising to 75% or more in established cases [2], and it was clear that this high mortality was not due simply to the inadequacy of antibiotics.

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Authors
  1. J. Cohen
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Editors and Affiliations

  1. Department of Anesthesiology, Centre Hospitalier, Universitaire de Liège, B-35 Domaine Universitaire du Sart Tilman, 4000, Liège, Belgium

    Maurice Lamy

  2. Department of Intensive Care, Free University Hospital, De Boelelaan 1117, 1007, MS, Amsterdam, The Netherlands

    Lambert G. Thijs

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© 1992 Springer-Verlag Berlin Heidelberg

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Cohen, J. (1992). Experimental Basis of New Therapeutic Approaches to Septic Shock. In: Lamy, M., Thijs, L.G. (eds) Mediators of Sepsis. Update in Intensive Care and Emergency Medicine, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84827-8_21

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  • DOI: https://doi.org/10.1007/978-3-642-84827-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84829-2

  • Online ISBN: 978-3-642-84827-8

  • eBook Packages: Springer Book Archive

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