Experimental Basis of New Therapeutic Approaches to Septic Shock

  • J. Cohen
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 16)


In 1982, the distinguished scientist, David Tyrrell, wrote a monograph entitled “ The Abolition of Infection: Hope or Illusion?” [1]. In it, he drew attention to the fact that the long-expected demise of infection as a “problem” was evidently not going to happen. Issues such as the development of antibiotic resistance in common bacteria, and the contribution of the host to the pathophysiological disease would, he said, require new and innovative approaches to the treatment of infection. The need for these new strategies was particularly apparent in the case of septic shock. Mortality was “stuck”, rising to 75% or more in established cases [2], and it was clear that this high mortality was not due simply to the inadequacy of antibiotics.


Tumor Necrosis Factor Septic Shock Bacterial Challenge Human Septic Shock Recombinant Human Tumor Necrosis 
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© Springer-Verlag Berlin Heidelberg 1992

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  • J. Cohen

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