Abstract
During the last decade, numerous studies of the effects of exercise on the immune system have been performed. Owing to the development and improvement of techniques for studying immune function in vitro as well as in vivo, there is at present a large body of data suggesting that strenuous exercise triggers an inflammatory response similar to that occurring in the presence of bacterial infection or tissue injury [1].
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cannon JG, Evans WJ, Hughes VA, Meredith CN, Dinarello CA (1986) Physiological mechanisms contributing to increased interleukin-1 secretion. J Appl Physiol 61:1869–1874
McCarthy DA, Dale MM (1988) The leucocytosis of exercise. A review and model. Sports Med 6:333–363
Cannon JG, Fielding RA, Fiatarone MA, Orencole SF, Dinarello CA, Evans WJ (1989) Increased interleukin 1ß in human skeletal muscle after exercise. Am J Physiol 257:451–455
Cannon JG, Orencole SF, Fielding RA, et al. (1990) Acute phase response in exercise: Interaction of age and vitamin E on neutrophils and muscle enzyme release. Am J Physiol 259:1214–1219
Dufaux B, Order U (1989) Plasma elastase-α1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise. Int J Sports Med 10:434–438
Camus G, Pincemail J, Lamy M (1991) Is there an analogy between sepsis and strenuous physical exercise in the process of neutrophil activation in man: A working hypothesis. In: Vincent JL (ed) Update in intensive Care and Emergency Medicine Vol 14, Springer Verlag, Berlin Heidelberg, pp 206–212
Pincemail J, Camus G, Roesgen A, et al. (1990) Exercise induces pentane production and neutrophil activation in humans. Effects of propranolol. Eur J Appl Physiol 61:319–322
Hansen JB, Wilsgård L, østerud B (1991) Biphasic changes in leukocytes induced by strenuous exercise. Eur J Appl Physiol 62:157–161
Schaefer RM, Kokot K, Heidland A, Plass R (1987) Jogger’s leukocytes. N Engl J Med 316:223–224
Smith LL (1991) Acute inflammation: The underlying mechanism in delayed onset muscle soreness? Med Sci Sports Exerc 23:542–551
Bosenberg AT, Brock-Utne JG, Gaffin SL, Wells MTB, Blake GTW (1988) Strenuous exercise causes systemic endotoxemia. J Appl Physiol 65:106–108
Camus G, Pincemail J, Duchateau J, et al. (1992) Complement and polymorphonuclear neu-trophil activation during submaximal dynamic exercise in man. Arch Int Physiol Biochim (Abs) (in press)
Morrison DC, Ryan JL (1987) Endotoxins and disease mechanisms. Ann Rev Med 320:365–376
Hack CE, Thijs LG (1991) The orchestra of mediators in the pathogenesis of septic shock: A review. In: Vincent JL (ed) Update in intensive care and emergency medicine Vol 14, Springer Verlag, Berlin Heidelberg, pp 232–246
Arai K, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T (1990) Cytokines: Coordinators of immune and inflammatory responses. Ann Rev Biochem 59:783–836
Parratt JR, Pacitti N (1987) The possible roles of lipoxygenase products of arachidonic acid metabolism and of platelet activating factor in shock. In: Vincent JL, Thijs LG (eds) Update in intensive care and emergency medicine Vol 4, Springer Verlag, Berlin Heidelberg, pp 74–88
Larsen GL, Henson PM (1983) Mediators of inflammation. Ann Rev Immunol 1:335–359
Gay JC (1990) Priming of neutrophil oxidative responses by platelet-activating factors. J Li-pid Mediat 2:161–175
Shalaby MB, Aggarwal BB, Rinderkwecht E, Svedersky LP, Finkle BS, Palladino MA (1985) Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol 135:2069–2073
Yancey KB (1988) Biological properties of human C5a: Selected in vitro and in vivo studies. Clin Exp Immunol 71:207–210
Aasen AO (1987) The role of proteolytic enzyme systems with particular emphasis on the plasma kallikrein-kinin system during septicemia and septic shock. In: Vincent JL, Thijs LG (eds) Update in intensive care and emmergency medicine Vol 4, Springer Verlag, Berlin Heidelberg pp 116–128
Schoenberg MH (1987) The participation of oxygen free radicals in septic shock. In: Vincent JL, Thijs LG (eds) Update in intensive care and emergency medicine Vol 4, Springer Verlag, Berlin Heidelberg pp 108–115
Maughan RJ, Donnelly AE, Gleeson M, et al. (1989) Delayed-onset muscle damage and lipid peroxidation in man following a downhill ran. Muscle & Nerve 12:332–336
Schwane JA, Johnson SR, Vandenakker CB, Armstrong RB (1983) Delayed-onset muscular soreness and plasma CPK and LDH activities after downhill running. Med Sci Sports Exerc 15:51–56
Bobbert MF, Hollander AP, Huijing PA (1986) Factors in delayed onset soreness of man. Med Sci Sports Exerc 18:75–81
Camus G, Sondag D, Maggipinto J, et al. (1991) Mobilisation des leucocytes lors de l’ exercice dynamique sous-maximum. Arch Int Physiol Biochim 99:419–423
Dufaux B, Order U (1989) Complement activation after prolonged exercise. Clin Chim Acta 179:45–50
Cannon JG, Kluger MJ (1983) Endogenous pyrogen activity in human plasma after exercise. Science Wash DC 220:617–619
Liesen H, Dufaux B, Hollmann W (1977) Modifications of serum glycoproteins the days following prolonged physical exercise and the influence of physical training. Eur J Appl Physiol 37:243–254
Taylor C, Rogers G, Goodman C, et al. (1987) Hematologie, iron-related, and acute-phase protein responses to sustained strenuous exercise. J Appl Physiol 62:464–469
Viti A, Muscettola M, Paulescu L, Bocci V, Almi A (1985) Effect of exercise on plasma in-terferon levels. J Appl Physiol 59:426–428
Newham DJ, Jones DA, Clarkson PM (1987) Repeated high force eccentric exercise: Effects on muscle pain and damage. J Appl Physiol 63:1381–1386
Wheeler ME, Davis GL, Gillespie WJ, Bern MM (1986) Physiological changes in hemostasis associated with acute exercise. J Appl Physiol 60:986–990
Hansen JB, Wilsgård L, Olsen JO, Osterud B (1990) Formation and persistence of procoagulant and fibrinolytic activities in circulation after strenuous physical exercise. Thromb Hae-most 64:385–389
Röcker L, Drygas WK, Heyduck B (1986) Blood platelet activation and increase in thrombin activity following a marathon race. Eur J Appl Physiol 55:374–380
Davies KJA, Quintanilha AT, Brooks GA, Packer L (1982) Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun 107:1198–1205
Jackson MJ, Edwards RHT, Symons MCR (1985) Electron spin resonance studies of intact mammalian skeletal muscle. Biochim Biophys Acta 847:185–190
Sjödin B, Westing YH, Apple FS (1990) Biochemical mechanisms for oxygen free formation during exercise. Sports Med 10:236–254
Pincemail J, Deby C, Camus G, et al. (1988) Tocopherol mobilization during intensive exercise. Eur J Appl Physiol 57:189–191
Duthie GG, Robertson JD, Maughan RJ, Morrice PC (1990) Blood antioxidant status and erythrocyte lipid peroxidation following distance running. Arch Biochem Biophys 282:78–83
Hochstein P, Jain SK (1981) Association of lipid peroxidation and polymerization of membrane proteins with erythrocyte aging. Fed proc 40:183–188
Camus G, Pincemail J, Ledent M, et al. (1992) Plasma levels of polymorphonuclear elastase and myeloperoxidase after uphill walking and downhill running at similar energy cost. Int J Sports Med (in press)
Hikida RS, Staron RS, Hagerman FC, Sherman WN, Costill DL (1983) Muscle fiber necrosis associated with human marathon runners. J Neurol Sci 59:185–203
Armstrong RB (1986) Muscle damage and endurance events. Sports Med 3:370–381
Damas P, Leclercq P, Vrindts Y, et al. (1992) The metabolic response after abdominal surgery. Acta Anaesth Scand (in press)
Damas P, Ledoux D, Nys M, et al. (1992) Cytokines serum levels during severe sepsis in human. IL-6 as a marker of severity. Ann Surg 215:356–362
Fitzgerald L (1991) Overtraining increases the susceptibility to infection. Int J Sports Med 12:5–8
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Camus, G., Pincemail, J., Lamy, M. (1992). Sepsis and Strenuous Exercise: Common Inflammatory Factors. In: Lamy, M., Thijs, L.G. (eds) Mediators of Sepsis. Update in Intensive Care and Emergency Medicine, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84827-8_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-84827-8_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84829-2
Online ISBN: 978-3-642-84827-8
eBook Packages: Springer Book Archive