Oxyradical Pathogenesis in Sepsis

  • J. J. Zimmerman
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 16)


Evidence implicating the participation of toxic oxygen radical species in the pathogenesis of sepsis is rapidly accumulating. Currently most of this information relates to cell culture and animal models, although some human clinical interventional studies employing oxygen radical scavengers are beginning to appear. This chapter will summarize a variety of evidence which indicates oxygen radical pathogenesis in sepsis and alludes to how this data may be utilized in the near future to design novel sepsis therapeutic agents.


Lipid Peroxidation Adult Respiratory Distress Syndrome Mitochondrial Electron Transport Chain Circ Shock Endotoxin Shock 
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© Springer-Verlag Berlin Heidelberg 1992

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  • J. J. Zimmerman

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