The French Multicenter Trial: Results and Conclusions

  • C. Marchal
  • B. Prevost
  • J.-M. Ardiet
  • J.-P. Gerard
  • J.-M. Cosset
Part of the Medical Radiology book series (MEDRAD)


Investigations into the use of interstitial hyperthermia started in France in 1977 at the Institut Gustave Roussy, with the preliminary works of Lebourgeois et al. (1978) followed by the physical works of Damia (1981) and the clinical experience of Cosset et al. (1982). This preliminary clinical experience was gained using parallel implanted needles and a home-made prototype built by the electronic laboratory of the Institut Gustave Roussy, and, later, using the first CGR Minerve system consisting of three generators of 25 W each operating at 0.5–1 MHz.


Mobile Tongue Complete Tumor Response Microwave Radiometry Recurrent Squamous Cell Carcinoma Preliminary Clinical Experience 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Chive M, Prevost B (1991) Technical aspects and clinical evaluation of a microwave interstitial hyperthermia system using a multifrequency radiometric technique for temperature control and monitoring. Strahlenther Onkol 167: 51Google Scholar
  2. Cosset JM (1990) Interstitial hyperthermia. In: Gautherie M (ed) Clinical thermology: interstitial, endocavitary and perfusional hyperthermia. Methods and clinical trials. Springer, Berlin Heidelberg New York, p 142Google Scholar
  3. Cosset JM, Brule JM, Salama AM, Damia E, Dutreix J (1982) Low-frequency (0.5 MHz) contact and interstitial techniques for clinical hyperthermia. In: Gautherie M (ed) Biomedical thermology. Alan R. Liss, New York, pp 649–657Google Scholar
  4. Cosset JM, Dutreix J, Dufour J, Janoray P, Damia E, Haie C, Clarke D (1984a) Combined interstitial hyperthermia and brachytherapy: the Institut Gustave Roussy experience. In: Jens Overgaard (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 587–590Google Scholar
  5. Cosset JM, Dutreix J, Dufour J, Janoray P, Damia E, Haie C, Clarke D (1984b) Combined interstitial hyperthermia and brachytherapy: Institut Gustave Roussy technique and preliminary results. Int J Radiat Oncol Biol Physics 10: 307–312CrossRefGoogle Scholar
  6. Cosset JM, Dutreix J, Haie C, Gerbaulet A, Janoray P, Dewars JA (1985) Interstitial thermoradiotherapy: a technical and clinical study of 29 implantations performed at the Institut Gustave Roussy. Int J Hyperthermia, 1: 3–13PubMedCrossRefGoogle Scholar
  7. Damia E (1981) Etude d’un systeme de chauffage a la frequence de 0.5 MHz pour l’hyperthermie therapeutique. These Faculte des Sciences de Limoges N°381Google Scholar
  8. Fabre JJ et al. (1990) Microwave interstitial hyperthermia controlled by multifrequency microwave radiometry: phase I trials. Innov Techn Biol Med 11: 236–248Google Scholar
  9. Fabre JJ, Camart JC (1991) Microwave interstitial hyperthermia system monitored by microwave radiometry (HIMCAR) and dosimetry by heating pattern remote sensing. Proc Eur Microwave Conference, Stuttgart, pp 1409–1414Google Scholar
  10. Fourquet A, Labib A, Campana F, Pontvert D, Gaboriaud G (1990) 192 Ir curietherapy and interstitial hyperthermia in primary breast cancer: preliminary results in 11 patients. Proc. ESTRO Meeting Sept 1990, p 257Google Scholar
  11. Gautherie M (1988) Clinical evaluation of the Minerve hyperthermia system: synthesis, T.V.P process (Ministry of Research and Technology (MRT) report)Google Scholar
  12. Gautherie M, Cosset JM, Gerard JP, Horiot JC, Ardiet JM, Akoun HEL, Alperovitch A (1988) Radiofrequency interstitial hyperthermia: A multicentre program of quality assessment and clinical trials. In: Sugahara J, Saito M (eds) In hyperthermic Oncology, vol 2. Taylor & Francis Publisher, pp 711–714Google Scholar
  13. Gérard JP, Romestaing P, Ardiet JM, Delaroche G, Mont-barbon X, Sentenac I, Cosset JM (1991) Interstitial hyperthermia: general overview and preliminary results. In: Urano F, Douple E (eds) Hyperthermia and oncology, vol 3. Springer, Berlin Heidelberg New York, pp 221–230Google Scholar
  14. Le Bourgeois JP, Convert G, Dufour J (1978) An interstitial device for microwave hyperthermia of human tumors. In: Streffer C (ed) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 122–124Google Scholar
  15. Marchal C, Hoffstetter S, Bey P, Pernot M, Gaulard ML (1985) Development of a new interstitial method of heating which can be used with conventional afterloading brachytherapy techniques using Ir 192. Strahlentherapie 161: 523–557Google Scholar
  16. Marchal C, Nadi M, Hoffstetter S, Bey P, Pernot M, Prieur G (1989) Practical interstitial method of heating operating at 27.12 MHz. Int J Hyperthermia 5: pp 451–466PubMedCrossRefGoogle Scholar
  17. Marchal C, Pernot M, Hoffstetter S, Bey P (1992) Clinical experience with different interstitial hyperthermia techniques. In: Handl-Zeller L (ed) Interstitial hyperthermia. Springer, Berlin Heidelberg New York, pp 207–228Google Scholar
  18. Nadi M, Marchal C, Tosser A, Roussey C, Gaulard ML (1988) New interstitial hypertehrmia technique at 27 MHz. Innov Tech Biol Med 9: 105–115Google Scholar
  19. Prevost B, Mirabel X, Chive M, Fabre JJ, Dubois L, Sozanski JP (1991a) Clinical evaluation of a microwave interstitial hyperthermia system with microwave radiometry. Strahlenther Onkol 167: 344Google Scholar
  20. Prévost B, Mirabel X, Coche B, Chive M, Fabre JJ, Sozanski JP (1991b). Hyperthermie interstitielle microonde com-binée à la curiethérapie dans le traitement des cancers de la langue. 2ème Congrès natl de la SFRO. Paris 12–13 Déc 1991. Bull Cancer (Paris) 78: 4–49Google Scholar
  21. Prevost B et al. (to be published) 915 MHz microwave interstitial hyperthermia, part III Phase II clinical results. Int J HyperthermiaGoogle Scholar
  22. Visser AG, Deurloo IKK, Van Rhoon GC, Levendag PC (1991) Evaluation of a capacitive coupling interstitial system. Selectron Brachytherapy J 5: 114–119Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • C. Marchal
    • 1
  • B. Prevost
    • 2
  • J.-M. Ardiet
    • 3
  • J.-P. Gerard
    • 4
  • J.-M. Cosset
    • 5
  1. 1.Unité d’Hyperthermie, Service de RadiothérapieCentre Alexis VautrinVandoeuvre les NancyFrance
  2. 2.Centre de lutte contre le cancer Oscar LambretLille CedexFrance
  3. 3.Service de CuriethérapieCentre Léon BérardLyonFrance
  4. 4.Service de RadiothérapieCentre Hospitalier Lyon SudPierre BeniteFrance
  5. 5.Département de RadiothérapieInstitut Gustave RoussyVillejuifFrance

Personalised recommendations