Interstitial Thermoradiotherapy for Pelvic Tumors: The City of Hope Experience

  • N. L. Vora
  • K. H. Luk
Part of the Medical Radiology book series (MEDRAD)


Interstitial techniques for radiation implants as primary or boost treatments have been practiced successfully by radiation oncologists for many years. When hyperthermia was found to be cytotoxic and synergistic with radiation, this modality was quickly combined with interstitial radioactive implantations. At the City of Hope National Medical Center, clinical trials with interstitial thermoradiotherapy commenced in 1984.


Curie Point Total Radiation Dose Pelvic Tumor Boost Treatment Hope National Medical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Astrahan MA, George FW II (1980) A temperature regulating circuit for experimental localized current field hyperthermia systems. Med Phys 7: 362–364PubMedCrossRefGoogle Scholar
  2. Atkinson WJ, Brezovich I A, Chakraborty DP et al. (1984) Usable frequencies in hyperthermia with thermal seeds. IEEE Trans Biomed Eng 31: 70–75PubMedCrossRefGoogle Scholar
  3. Brezovich I A, Atkinson WJ (1984) Temperature distributions in tumor models heated by self-regulating nickle-copper alloy thermoseeds. Med Phys 11: 145–152PubMedCrossRefGoogle Scholar
  4. Brezovich I A, Atkinson WJ, Lilly MB et al. (1984) Local hyperthermia with interstitial techniques. Cancer Res [Suppl] 44: 4752s–4756sGoogle Scholar
  5. Burton CV, Hill M, Walker AE et al. (1971) The RF thermal seed -a thermally self-regulating implant for the production of brain lesions. IEEE Trans Biomed Eng 18: 104–109PubMedCrossRefGoogle Scholar
  6. Corry P, Martinez A, Armour PE et al. Simultaneous hyperthermia and brachytherapy with remote afterloading. Proceedings brachytherapy meeting. Remote afterloading state-of-the-art. May 4–6, 1989Google Scholar
  7. Doss JD, McCabe CW (1976) A technique for localized heating in tissue: an adjunct to tumor therapy. Med Instrumentation 10: 16–21Google Scholar
  8. Prionas SD, Goffinet DR, Samulski TV et al. (1984) Characterization of an interstitial hyperthermia RF system utilizing flexible electrodes. Abstract of the 32nd Annual Meeting of the Rad. Res. Soc., Orlando, FL, March 25–29, p 18Google Scholar
  9. Stauffer PR, Thomas CC, Fletcher AM et al. (1984a) Observations in the use of ferromagnetic implants for inducing hyperthermia. IEEE Trans Biomed Eng 31: 76–90PubMedCrossRefGoogle Scholar
  10. Stauffer PR, Thomas CC, Jones RC et al. (1984b) Magnetic induction heating of ferromagnetic implants for inducing localized hyperthemia in deep-seated tumors. IEEE Trans Biomed Eng 31: 235–251PubMedCrossRefGoogle Scholar
  11. Vora N, Forell B, Joseph C et al. (1982) Interstitial implant with interstitial hyperthermia. Cancer 50: 2518–2523PubMedCrossRefGoogle Scholar
  12. Vora N, Shaw S, Forell B et al. (1986) Primary radiation combine with hyperthermia for advanced (Stage III–IV) and inflammatory carcinoma of breast. Endocurietherapy/Hyperthermia Oncol 2: 101–106Google Scholar
  13. Vora N, Luk K, Forell B et al. (1988) Interstitial local current field hyperthermia for advanced cancers of the cervix. Endocurietherapy/Hyperthermia Oncol 4: 97–106Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • N. L. Vora
    • 1
  • K. H. Luk
    • 2
  1. 1.Division of Radiation OncologyCity of Hope National Medical CenterDuarteUSA
  2. 2.Department of Radiation OncologyGood Samaritan Regional Medical CenterPhoenixUSA

Personalised recommendations