Clinical Experience of Interstitial Thermoradiotherapy Using Ferromagnetic Implant Techniques
Interstitial hyperthermia commands much current interest as a method for delivering localized heat treatment to deep-seated as well as superficial tumors. Several interstitial techniques have been developed and used clinically over the past two decades. Interstitial techniques are popular since they can circumvent some problems encountered with non-invasive hyperthermia techniques, such as limited penetration, inefficient and nonuniform power distribution, and excessive heating of adjacent normal tissues. On the other hand, interstitial hyperthermia is an invasive technique and it usually requires general anesthesia. Some patients with bleeding disorders may not be candidates for such an approach. Furthermore, due to the localized nature of the treatment, the resulting temperature distribution may be highly dependent on the blood flow and geometry of the implant. Three major classes of interstitial hyperthermic techniques have been described and developed: interstitial radiofre quency electrodes (IRF), interstitial microwave antennas (IMW), and hot source techniques.
KeywordsExternal Beam Radiotherapy Hyperthermia Treatment Extracranial Tumor Direct Energy Deposition Localize Heat Treatment
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- Aristizabal S, Oleson J (1984) Combined interstitial irradiation and localized current field hyperthermia: results and conclusions from clinical studies. Cancer Res 44: 4757–4760Google Scholar
- Au K, Cetas T, Shimm D et al. (1989) Interstitial ferromagnetic hyperthermia and brachytherapy; preliminary results of phase I clinical trial. Endocurietherapy/Hyperthermia Oncol 5: 127–136Google Scholar
- Gautherie M (1989) Interstitial hyperthermia: state of the art and prospects. In: Sugahara T, Saito M (eds) Hyperthermic oncology 1988, vol 2. Taylor & Francis, London, pp 63–68Google Scholar
- Puthawala AA, Syed AMN, Khalid MA, Rafie S, McNamara CS (1985) Interstitial hyperthermia for recurrent malignancies. Endocurietherapy/Hyperthermia Oncol 1: 125–131Google Scholar
- Seegenschmiedt MH, Sauer R, Brady L, Karlsson U (1992) Clinical practice of interstitial microwave hyperthermia combined with iridium-192 brachytherapy. In: Handl-Zeller L (ed) Interstitial hyperthermia. Springer, Wien New York, pp 135–154Google Scholar
- Shimm D, Kittelson J, Stea B (1991) Interstitial thermoradiotherapy, The University of Arizona experience. In: Urano M, Douple E (eds) Hyperthermia and oncology, vol 3. Zeist, VSP, Utrecht, The Netherlands, pp 181–198Google Scholar
- Stea B, Shimm D, Kittelson J, Cetas T (1992a) Interstitial hyperthermia with ferromagnetic seed implants: preliminary results of a phase I clinical trial. In: Handl-Zeller L (ed) Interstitial hyperthermia. Springer, Wein New York, pp 183–191Google Scholar
- Vora NL, Forell B, Luk KH, Pezner RD, Desai KR, Lipsett JA, Wong JYA (1989) Interstitial thermoradiotherapy in recurrent and advanced malignant tumors: seven years’ experience. In: Sugahara T, Saito M (eds) Hyperthermic oncology 1988, vol 1. Taylor & Francis, London, pp 588–590Google Scholar