Thermal Model Verification in Interstitial Hyperthermia

  • J. Crezee
  • J. Mooibroek
  • J. J. W. Lagendijk
Part of the Medical Radiology book series (MEDRAD)


In vivo tests are essential for the development and evaluation of interstitial hyperthermia systems, especially because determination of the threedimensional temperature distribution during clinical treatment is impossible: Minimal temperatures are expected to occur somewhere between the needles, requiring an extensive set of thermocouple catheters in addition to the applicator catheters. Usually the number of catheters implanted is already a compromise between the need for a small catheter spacing to ensure uniform temperatures and the wish to prevent excessive trauma to the patient. Any extra catheters available one might prefer to use for extra interstitial needles to improve temperature homogeneity. One must therefore be able to rely on the accuracy and correctness of the computed small scale temperature distribution.


Heat Sink Large Vessel Bioheat Transfer Cool Spot Bioheat Equation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Babbs CF, Fearnot NE, Marchosky JA, Moran CJ, Jones JT, Plantenga TD (1990) Theoretical basis for controlling minimal tumor temperature during interstitial conductive heat therapy. IEEE Trans Biomed Eng 37: 662–672PubMedCrossRefGoogle Scholar
  2. Bos CK, Crezee J, Mooibroek J, Lagendijk JJW (1991) A perfusion technique for tongues to be used in bioheat transfer studies. Phys Med Biol 36: 843–846PubMedCrossRefGoogle Scholar
  3. Brezovich IA, Atkinson WJ (1984) Temperature distributions in tumor models heated by self-regulating nickel-copper alloy thermoseeds. Med Phys 11: 145–152PubMedCrossRefGoogle Scholar
  4. Chen MM, Holmes KR (1980) Micro vascular contributions in tissue heat transfer. Ann NY Acad Sci 335: 137–151PubMedCrossRefGoogle Scholar
  5. Cosset JM, Bichler K-H, Strohmaier WL et al. (1990) Interstitial, endocavitary and perfusional hyperthermia. Methods and clinical trials. Springer, Berlin Heidelberg New York, pp 1–41CrossRefGoogle Scholar
  6. Crezee J, Lagendijk JJW (1990) Experimental verification of bioheat transfer theories: measurement of temperature profiles around large artificial vessels in perfused tissue. Phys Med Biol 35: 905–923PubMedCrossRefGoogle Scholar
  7. Crezee J, Lagendijk JJW (1992) Temperature uniformity during hyperthermia: the impact of large vessels. Phys Med Biol 37: 1321–1337PubMedCrossRefGoogle Scholar
  8. Crezee J, Mooibroek J, Bos CK, Lagendijk JJW (1991) Interstitial heating: experiments in artificially perfused bovine tongues. Phys Med Biol 36: 823–833PubMedCrossRefGoogle Scholar
  9. Deford JA, Babbs CF, Patel UH, Bleyer MW, Marchosky JA, Moran CJ (1991) Effective estimation and computer control of minimum tumour temperature during conductive interstitial hyperthermia. Int J Hyperthermia 7: 441–454PubMedCrossRefGoogle Scholar
  10. DeYoung DW, Kundrat MA, Cetas TC (1986) In vivo kidneys as preclinical thermal models for hyperthermia. Proceedings of the IEEE/9th Annual Conference of the Medical and Biological Society (Boston: IEEE No. 87CH2513–0): 994–996Google Scholar
  11. Goffinet DR, Prionas SD, Kapp DS et al. (1990) Interstitial 192Ir flexible catheter radiofrequency hyperthermia treatments of head and recurrent pelvic carcinomas. Int J Radiat Oncol Biol Phys 18: 199–210PubMedCrossRefGoogle Scholar
  12. Hand JW, Trembly BS, Prior MV (1992) Physics of interstitial hyperthermia. Radiofrequency and hot water tube techniques. In: Urano M, Douple E (eds) Hyperthermia and oncology, vol 3: Interstitial hyperthermia. European Book Service, de Meern, pp 99–134Google Scholar
  13. Handl-Zeller L, Karcher KH, Schreier K, Handl O (1986) Beitrag zur optimierung interstitieller hyperthermie-systeme. Strahlentherapie 163: 460–463Google Scholar
  14. Holmes KR, Ryan W, Weinstein P, Chem MM (1984) A fixation technique for organs to be used as perfused tissue phantoms in bioheat transfer studies. Adv Bioeng ASME WAM: 9–10Google Scholar
  15. Lagendijk JJW (1982) The influence of blood flow in large vessels on the temperature distribution in hyperthermia. Phys Med Biol 27: 17–23PubMedCrossRefGoogle Scholar
  16. Lagendijk JJW (1984) A new theory to calculate temperature distributions in tissues, or why the “bioheat transfer” equation does not work. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor & Francis, London, pp 507–510Google Scholar
  17. Lagendijk JJW (1990) Thermal models: principles and implementation. In: Field SB, Hand JW (eds) An introduction to the practical aspects of clinical hyperthermia. Taylor & Francis, London, pp 478–512Google Scholar
  18. Mechling JA, Strohbehn JW (1986) A theoretical comparison of the temperature distributions produced by three interstitial hyperthermia systems. Int J Radiat Oncol Biol Phys 12: 2137–2149PubMedCrossRefGoogle Scholar
  19. Milligan AJ, Conran PB, Ropar MA, McCulloch HA, Ahuja RK, Dobelbower RR (1983) Predictions of blood flow from thermal clearance during regional hyperthermia. Int J Radiat Oncol Biol Phys 9: 1335–1343PubMedCrossRefGoogle Scholar
  20. Mooibroek J, Lagendijk JJW (1991) A fast and simple algorithm for the calculation of convective heat transfer by large vessels in three dimensional inhomogeneous tissues. IEEE Trans Biomed Eng 38: 490–501PubMedCrossRefGoogle Scholar
  21. Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1: 93–122PubMedGoogle Scholar
  22. Schreier K, Budihna M, Lesnicar H et al. (1990) Preliminary studies of interstitial 1 hyperthermia using hot water. Int J Hyperthermia 6: 431–444PubMedCrossRefGoogle Scholar
  23. Stauffer PR, Sneed PK, Suen SA, Satoh T, Matsumoto K, Fike JR, Philips TL (1989) Comparative thermal dosimetry of interstitial microwave and radiofrequency-LCF hyperthermia. Int J Hyperthermia 5: 307–318PubMedCrossRefGoogle Scholar
  24. Strohbehn JW (1983) Temperature distributions from interstitial rf electrode hyperthermia systems: theoretical predictions. Int J Radiat Oncol Biol Phys 9: 1655–1667PubMedGoogle Scholar
  25. Strohbehn JW, Trembly BS, Douple EB (1982) Blood flow effects on the temperature distributions from an invasive microwave antenna array used in cancer therapy. IEEE Trans Biomed Eng 29: 649–661PubMedCrossRefGoogle Scholar
  26. Uzunoglu NK, Nikita KS (1988) Estimation of temperature distribution inside tissues heated by interstitial RF electrode hyperthermia systems. IEEE Trans Biomed Eng 35: 250–256PubMedCrossRefGoogle Scholar
  27. Weinbaum S, Jiji LM (1985) A new simplified bioheat equation for the effect of blood flow on local average tissue temperature. AS ME J Biomech Eng 107: 131–139CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. Crezee
    • 1
  • J. Mooibroek
    • 1
  • J. J. W. Lagendijk
    • 1
  1. 1.Department of RadiotherapyUniversity Hospital UtrechtUtrechtThe Netherlands

Personalised recommendations