Growth Factors and Angiogenesis in Breast Cancer
An overview of adjuvant therapy in breast cancer has shown the long-term survival benefits in node-positive and-negative cases  (reprinted in part in this volume). However, these treatments have still made only a relatively small impact on mortality, i.e. an increase in 10-year survival from 45% to 51.3% overall and from 39.8% to 46.6% in node-positive cases. Thus, the majority still die from their cancer. Greater understanding of the mechanisms of tumour growth and metastasis may enable the rational development of new agents to complement the achievements of hormone and chemotherapy.
KeywordsToxicity Doxorubicin Methotrexate NADPH Fluorouracil
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