From the Overview to the Patient: How To Interpret Meta-analysis Data
Clinical investigators have not easily accepted the concept of meta-analysis. Those who perform these formal statistical combinations of data from several different trials have been referred to as “those burgeoning band of interlopers, the meta-analysts” . Critics have referred to meta-analysis as “pooling, drowning, and floating” in the past , and even today many view the exercise as potentially dangerous, and clearly a threat to the integrity and importance of the individual clinical trial [3, 4].
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