Trials of Breast Conservation: A Critical Review of All Options

  • W. C. Wood
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 127)


The role of breast conservation in the local management of primary breast cancer is in evolution today. The first major clinical question addressed was the adequacy of therapy that spared the breast as compared with total mastectomy. A series of trials in single institutions suggested relative equivalence of local and regional control with a combination of excisional tumor surgery, axillary dissection, and breast irradiation [1]. Many breast surgeons, who remain the primary health care providers making an initial diagnosis, continued to harbor anxiety about the systemic effects and ultimate survival of patients treated with differing local therapies.


Breast Cancer Local Control Primary Breast Cancer Early Breast Cancer Axillary Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dorr A (1992) NIH Consensus Development Conference on the management of early breast cancer. J Natl Cancer Inst Monogr 11Google Scholar
  2. 2.
    Osteen RT, Steel GD Jr, Menck HR, Winchester DP (1992) Regional differences in surgical management of breast cancer. CA 42:39–43PubMedCrossRefGoogle Scholar
  3. 3.
    Sarrazin D, Le MG, Arrigada R et al. (1989) Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol 14:177–184PubMedCrossRefGoogle Scholar
  4. 4.
    Gelman R, Gelber R, Henderson IC et al. (1990) Improved methodology for analyzing local and distant recurrence. J Clin Oncol 8:548–555PubMedGoogle Scholar
  5. 5.
    Fisher B, Anderson S, Fisher E et al. (1991) Significance of ipsilateral breast tumor recurrence after lumpectomy. Lancet 338:327–331PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • W. C. Wood
    • 1
  1. 1.Department of SurgeryEmory University School of MedicineAtlantaUSA

Personalised recommendations