Trials of Breast Conservation: A Critical Review of All Options
The role of breast conservation in the local management of primary breast cancer is in evolution today. The first major clinical question addressed was the adequacy of therapy that spared the breast as compared with total mastectomy. A series of trials in single institutions suggested relative equivalence of local and regional control with a combination of excisional tumor surgery, axillary dissection, and breast irradiation . Many breast surgeons, who remain the primary health care providers making an initial diagnosis, continued to harbor anxiety about the systemic effects and ultimate survival of patients treated with differing local therapies.
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