Skip to main content
SpringerLink
Log in

Review of Proliferative Variables and Their Predictive Value

  • Conference paper
Adjuvant Therapy of Breast Cancer IV

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 127))

Abstract

The growing interest in breast cancer biology and the development of sophisticated techniques have greatly contributed to the knowledge of cellular and molecular aspects of disease progression. Markers indicative of biological aggressiveness have been identified [1], and some of these have already passed from the laboratory to clinical application as valid prognostic indicators.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Merkel DE, Osborne K (1989) Prognostic factors in breast cancer. Hematol Oncol Clin North Am 3:641–652

    PubMed  CAS  Google Scholar 

  2. Tubiana M, Pejovic MH, Chavaudra G, Contesso G, Malaise EP (1984) The long-term prognostic significance of the thymidine labeling index in breast cancer. Int J Cancer 33:441–445

    Article  PubMed  CAS  Google Scholar 

  3. Gentili C, Sanfilippo O, Silvestrini R (1981) Cell proliferation and its relationship to clinical features and relapse in breast cancer. Cancer 48:974–979

    Article  PubMed  CAS  Google Scholar 

  4. Meyer JS, Friedman E, McCrate MM, Bauer WC (1983) Prediction of early course of breast carcinoma by thimidine labeling. Cancer 51:1879–1886

    Article  PubMed  CAS  Google Scholar 

  5. Quinn CM, Wright NA (1990) The clinical assessment of proliferation and growth in human tumours: evaluation of methods and applications as prognostic variables. J Pathol 160:93–102

    Article  PubMed  CAS  Google Scholar 

  6. McGuire WL (1991) Breast cancer prognostic factors: evaluation guidelines. J Natl Cancer Inst 83:154–155

    Article  PubMed  CAS  Google Scholar 

  7. Sahin AA et al. (1991) Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Cancer 68:549–557

    Article  PubMed  CAS  Google Scholar 

  8. Bouzubar N, Walker KJ, Griffiths K et al. (1989) Ki67 immunostaining in primary breast cancer: pathological and clinical associations. Br J Cancer 59:943–947

    Article  PubMed  CAS  Google Scholar 

  9. Wintzer HO, Zipfel I, Schulte-Monting J, Hellerich U, von Keist S (1991) Ki-67 immunostaining in human breast cancer tumors and its relationship to prognosis. Cancer 67:421–428

    Article  PubMed  CAS  Google Scholar 

  10. Stauch G, Lelle RJ, Broermann L, Gerogii A (1988) Comparison of prognosis factors in breast cancer: grading of malignancy according to Bloom and Richardson versus determination of Ki67 growth fraction. Verh Dtsch Ges Pathol 72:256–259

    PubMed  CAS  Google Scholar 

  11. Weilken W, Beck T, Mitze M, Knapstein PG (1991) Immunohistochemical evaluation of growth fractions in human breast cancers using monoclonal antibody Ki-67. Breast Cancer Res Treat 18:149–154

    Article  Google Scholar 

  12. Brown RW, Allred DC, Clark GM, Tandon AK, McGuire WL (1990) Prognostic significance and clinical-pathological correlations of cell-cycle kinetics measured by Ki-67 immunohistochemistry in axillary node-negative carcinoma of the breast. Breast Cancer Res Treat 16:192

    Google Scholar 

  13. Gasparini G, Dal Fior S, Pozza F, Bevilacqua P (1989) Correlation of growth fraction by Ki-67 immunohistochemistry with histologic factors and hormone receptors in operable breast carcinoma. Breast Cancer Res Treat 14:329–336

    Article  PubMed  CAS  Google Scholar 

  14. Gerdes J, Lelle RJ, Pickartz H et al. (1986) Growth fractions in breast cancers determined in situ with a monoclonal antibody Ki67. J Clin Pathol 39:977–980

    Article  PubMed  CAS  Google Scholar 

  15. Isola J, Helin HJ, Helle MJ, Kallioniemi OP (1990) Evaluation of cell proliferation in breast carcinoma: comparison of Ki67 immunohistochemical study, DNA flow cytometric analysis, and mitotic count. Cancer 65: 1180–1185

    Article  PubMed  CAS  Google Scholar 

  16. McGurrin JF, Doria MI Jr, Dawson PJ, Karrison T, Stein HO, Franklin WA (1987) Assessment of tumor cell kinetics by immunohistochemistry in carcinoma of the breast. Cancer 59:1744–1750

    Article  PubMed  CAS  Google Scholar 

  17. Veneroni S, Silvestrini R, Costa A (1991) Relationship between 3H-TdR labeling index and Ki-67 in human breast cancer. J Biol Marker 6:68

    Google Scholar 

  18. Veronese S, Gambacorta M (1991) Detection of Ki-67 proliferation rate in breast cancer. Correlation with clinical and pathologic features. Am J Clin Pathol 95:30–34

    PubMed  CAS  Google Scholar 

  19. Clark GM, Dressier LG, Owens MA, Pounds G, Oldaker T, McGuire WL (1989) Prediction of relapse or survival in patients with node-negative breast cancer by DNA flow cytometry. N Engl J Med 320:627–633

    Article  PubMed  CAS  Google Scholar 

  20. O’Reilly SM, Camplejohn RS, Barnes DM, Millis RR, Rubens RD, Richards MA (1990) Node-negative breast cancer: prognostic subgroup defined by tumor size and flow cytometry. J Clin Oncol 8:2040–2046

    PubMed  Google Scholar 

  21. Sigurdsson H, Baldetorp B, Borg A et al. (1990) Indicators of prognosis in node-negative breast cancer. N Engl J Med 322:1045–1053

    Article  PubMed  CAS  Google Scholar 

  22. Fisher B, Nurten G, Costantino J et al. (1991) DNA flow cytometric analysis of primary operable breast cancer. Cancer 68:1465–1475

    Article  PubMed  CAS  Google Scholar 

  23. Daidone MG, Silvestrini R, Del Bino G, Di Fronzo G (1991) Autoradiographic and flow cytometric estimations of S-phase cell fraction in node-negative (N-) breast cancer: biologic and clinical comparison (Abstr). Proc Am Soc Clin Oncol 10:47

    Google Scholar 

  24. Muss H, Kute TE, Case LD et al. (1989) The relation of flow cytometry to clinical and biologic characteristics in women with node negative primary breast cancer. Cancer 64:1894–1900

    Article  PubMed  CAS  Google Scholar 

  25. Silvestrini R (1991) Feasibility and reproducibility of the 3H-thymidine labelling index in breast cancer. Cell Prolif 24:437–445

    Article  PubMed  CAS  Google Scholar 

  26. Meyer JS, Prey MU, Babcock DS (1986) Breast carcinoma cell kinetics, morphology, stage, and host characteristics. Lab Invest 54:41–51

    PubMed  CAS  Google Scholar 

  27. Tubiana M, Pejovic MH, Koscielny S, Chavaudra N, Malaise E (1989) Growth rate, kinetics of tumor cell proliferation and long-term outcome in human breast cancer. Int J Cancer 44:17–22

    Article  PubMed  CAS  Google Scholar 

  28. Hery M, Gioanni J, Lalanne CM, Namer M, Courdi A (1987) The DNA labeling index: a prognostic factor in node-negative breast cancer. Breast Cancer Res Treat 9:207–212

    Article  PubMed  CAS  Google Scholar 

  29. Silvestrini R, Daidone MG, Valagussa P, Di Fronzo G, Mezzanotte G, Bonadonna G (1989) Cell kinetics as a prognostic indicator in node-negative breast cancer. Eur J Cancer 25:1165–1171

    Article  CAS  Google Scholar 

  30. Meyer JS, Province M (1988) Proliferative index of breast carcinoma by thymidine labeling: prognostic power independent of stage, estrogen and progesterone receptors. Breast Cancer Res Treat 12:191–199

    Article  PubMed  CAS  Google Scholar 

  31. Paradiso A, Mangia A, Picciariello M et al. (1992) Fattori prognostici nel carcinoma della mammella operabile N-: attività proliferativa e caratteristiche clinico patologiche. Folia Oncol 13:1–13

    Google Scholar 

  32. Daidone MG, Silvestrini R, D’Errico A et al. (1991) Laminin receptors, collagenase IV and prognosis in node-negative breast cancer. Int J Cancer 48:529–532

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

    R. Silvestrini & M. G. Daidone

Authors
  1. R. Silvestrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. G. Daidone
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medicine C, Kantonsspital, CH-9007, St. Gallen, Switzerland

    Hans-Jörg Senn  & Beat Thürlimann  & 

  2. Division of Biostatistics, Dana Farber Cancer Institute, 44, Binney Street, Boston, MA, 02115, USA

    Richard D. Gelber Ph.D.

  3. Ospedale Civico, CH-6900, Lugano, Switzerland

    Aron Goldhirsch

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Silvestrini, R., Daidone, M.G. (1993). Review of Proliferative Variables and Their Predictive Value. In: Senn, HJ., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Breast Cancer IV. Recent Results in Cancer Research, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84745-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84745-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84747-9

  • Online ISBN: 978-3-642-84745-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation