Skip to main content

Intrinsic Antibiotic Resistance in Pseudomonas Aeruginosa

  • Conference paper

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1992))

Abstract

Pseudomonas aeruginosais a formidable opportunistic pathogen. Pseudomonal infections are very common among hospitalized patients, particularly in the ICU. They are notoriously difficult to treat and account for substantial morbidity and mortality. One of the major factors contributing to the high death rate associated with these infections is the broad resistance to common antimicrobial agents which typifies this organism. One of the least well understood aspects of this resistance is the barrier effect of the outer membrane. In this chapter, I will briefly survey newer information pertaining to the role of cell wall barriers as mechanisms of antibiotic resistance in P. aeruginosa.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Yoshimura FH, Nikaido H (1982) Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J Bacteriol 152:636–642

    PubMed  CAS  Google Scholar 

  2. Nikaido H (1992) Non-specific and specific permeability channels of the Pseudomonas aeruginosa outer membrane. In: Galli E, Silver S, Witholt B (eds) Pseudomonas: Molecular Biology and Biotechnology, American Society for Microbiology, Washington, DC (in press)

    Google Scholar 

  3. Quinn JP, Dudek EJ, DiVincenzo CA, Lucks DA, Lerner SA (1986) Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections. J Infect Dis 154:289–294

    Article  PubMed  CAS  Google Scholar 

  4. Livermore DM, Yang YJ (1987) Beta-lactamase lability and inducer power of newer beta-lactam antibiotics in relation to their activity against beta-lactamase-inducibility mutants of Pseudomonas aeruginosa. J Infect Dis 155:775–778

    Article  PubMed  CAS  Google Scholar 

  5. Quinn JP, Darzins A, Miyashiro D, Ripp S, Miller RV (1991) Imipenem resistance in Pseudomonas aeruginosa PAO: Mapping of the OprD2 gene. Antimicrob Agents Chemother 35:753–755

    PubMed  CAS  Google Scholar 

  6. Nakae T (1991) (Tokai University, Isehara, Japan). Personal communication

    Google Scholar 

  7. Watanabe N, Nagasu T, Katsu K, Kitoh K (1987) E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrob Agents Chemother 31:497–504

    PubMed  CAS  Google Scholar 

  8. Pugsley AP, Schnaitman C (1978) Outer membrane proteins of Escherichia coli. VII Evidence that bacteriophage-directed protein 2 functions as a porin. J Bacteriol 133:1181–1189

    PubMed  CAS  Google Scholar 

  9. Burns JL, Mendelman PM, Levy J, Stull TL, Smith AL (1985) A permeability barrier as a mechanism of chloramphenicol resistance in Haemophilus influenzae. Antimicrob Agents Chemother 27:46–54

    PubMed  CAS  Google Scholar 

  10. Burns JL, Rubens CE, Mendelman PM, Smith AL (1986) Cloning and expression in Escherichia coli of a gene encoding nonenzymatic chloramphenicol resistance from Pseudomonas aeruginosa. Antimicrob Agents Chemother 29:445–450

    PubMed  CAS  Google Scholar 

  11. Yoshida HM, Bogaki M, Nakamura M, Nakamura S (1990) Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob Agents Chemother 34:1271–1272

    PubMed  CAS  Google Scholar 

  12. Hooper DC, Wolfson JS, Souza KS, Tung C, McHugh GL, Swartz MN (1986) Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli. Antimicrob Agents Chemother 29:639–644

    PubMed  CAS  Google Scholar 

  13. Gutmann L, Williamson R, Moreau N et al. (1985) Cross-resistance to nalidixic acid, trime-thoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter, and Serratia. J Infect Dis 151:501–507

    Article  PubMed  CAS  Google Scholar 

  14. Vastola AP, Altschaefl J, Harford S (1980) 5-epi-sisomicin and 5-epi-gentamicin B: Substrates for aminoglycoside-modified enzymes that retain activity against aminoglycoside-resistant bacteria. Antimicrob Agents Chemother 17:798–802

    PubMed  CAS  Google Scholar 

  15. Hancock REW, Raffle VJ, Nicas TI (1981) Involvement of the outer membrane in gentami-cin and streptomycin uptake and killing in Pseudomonas aeruginosa. Antimicrob Agents Chemother 19:777–785

    PubMed  CAS  Google Scholar 

  16. Loh B, Grant C, Hancock REW (1984) Use of the fluorescent probe 1-N-phenylnaphthyl-amine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa. Antimicrob Agents Chemother 26:546–551

    PubMed  CAS  Google Scholar 

  17. Bryan LE, Nicas TI, Holloway BW, Crowther C (1980) Aminoglycoside-resistant mutation of Pseudomonas aeruginosa defective in cytochrome C553 and nitrate reductase. Antimicrob Agents Chemother 17:71–79

    PubMed  CAS  Google Scholar 

  18. Bryan LE, van den Elzen HM (1977) Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: A model for entry of streptomycin and gentamicin in susceptible and resistant bacteria. Antimicrob Agents Chemother 12:163–177

    PubMed  CAS  Google Scholar 

  19. McMurray LM, Cullinane JC, Petrucci RJ, Levy S (1981) Active uptake of tetracycline by membrane vesicles from susceptible Escherichia coli. Antimicrob Agents Chemother 20:307–313

    Google Scholar 

  20. Levy SB (1984) Resistance to the tetracyclines. In: Bryan LE (ed) Antimicrobial Drug Resistance, Academic Press, Orlando, pp 191–240

    Google Scholar 

  21. Cohen SP, Hooper DC, Wolfson JS, Souza KS, McMurray LM, Levy SB (1988) Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob Agents Chemother 32:1187–1191

    PubMed  CAS  Google Scholar 

  22. Yoshida HM, Bogaki M, Nakamura S, Ubukata K, Konno M (1990) Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J Bacteriol 172:6942–6949

    PubMed  CAS  Google Scholar 

  23. Celesk RA, Robillard NJ (1989) Factors influencing the accumulation of ciprofloxacin in Pseudomonas aeruginosa. Antimicrob Agents Chemother 33:1921–1926

    PubMed  CAS  Google Scholar 

  24. Ross JI, Eady EA, Cove JH, Cunliffe WJ, Baumberg S, Wostten JC (1990) Inducible ery-thromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family. Mol Microb 4:1207–1214

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Quinn, J.P. (1992). Intrinsic Antibiotic Resistance in Pseudomonas Aeruginosa. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1992. Yearbook of Intensive Care and Emergency Medicine, vol 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84734-9_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84734-9_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55241-3

  • Online ISBN: 978-3-642-84734-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics