Intrinsic Antibiotic Resistance in Pseudomonas Aeruginosa

  • J. P. Quinn
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1992)


Pseudomonas aeruginosais a formidable opportunistic pathogen. Pseudomonal infections are very common among hospitalized patients, particularly in the ICU. They are notoriously difficult to treat and account for substantial morbidity and mortality. One of the major factors contributing to the high death rate associated with these infections is the broad resistance to common antimicrobial agents which typifies this organism. One of the least well understood aspects of this resistance is the barrier effect of the outer membrane. In this chapter, I will briefly survey newer information pertaining to the role of cell wall barriers as mechanisms of antibiotic resistance in P. aeruginosa.


Outer Membrane Pseudomonas Aeruginosa Antimicrob Agent Tetracycline Resistance Aminoglycoside Resistance 
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© Springer-Verlag Berlin Heidelberg 1992

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  • J. P. Quinn

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