Cytokines and Cytokine Antagonists in Sepsis and Critical Illness
Mediators of the cytokine class are widely assumed to exert significant pathophysiological influences in septic and critically ill patients . Among the cytokines exhibiting significant proinflammatory characteristics, tumor necrosis factor (TNF) and interleukin-1 (IL-1) appear to be the most promising candidate mediators for promoting both the acute septic responses and the organ failure sequelae of sepsis. However, several prospective studies seeking to determine the incidence of circulating TNF and IL-1 in critically ill patients have failed to consistently detect these cytokines during clinical conditions consistent with their known biological functions [2, 3].
KeywordsCritical Illness Tumor Necrosis Factor Production Soluble Tumor Necrosis Factor Receptor Endotoxin Administration Tumor Necrosis Factor Activity
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