Tissue Hypoxia in Animal Models of Sepsis

  • S. M. Cain
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1992)


Pathological O2 supply dependency, as observed in some critically ill patients, has been described as an abnormal dependence of O2 uptake (VO2) upon O2 delivery (DO2) at levels of DO2 that are normally considered adequate [1]. In those patients who respond to an increase of DO2 by increasing VO2, the observations are consistent with:
  1. 1.

    increased O2 demands that are apparently not met,

  2. 2.

    an apparent inability to increase O2 extraction appropriately in response to any unmet O2 demand,

  3. 3.

    an elevated arterial lactate level that will decrease as DO2 and VO2 increase.



Tissue Hypoxia Citric Acid Cycle Adult Respiratory Distress Syndrome Blood Lactate Level Arterial Lactate 
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© Springer-Verlag Berlin Heidelberg 1992

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  • S. M. Cain

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