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Yearbook of Intensive Care and Emergency Medicine 1992 pp 194–203Cite as

The Alveolar Epithelial Barrier

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Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1992))

Abstract

The primary purpose of this chapter is to briefly review the results of both experimental and clinical studies that have been completed in the last decade and provide new insights into the role of the alveolar epithelial barrier in the resolution of both hydrostatic and increased permeability pulmonary edema. The first part of the review will provide some background information regarding important differences between hydrostatic and increased permeability pulmonary edema. The second part will consider the critical results from several experimental studies in our laboratory on the function of the alveolar epithelial barrier in both the normal and the injured lung in terms of removal of both excess liquid and protein from the air spaces of the lung. The third part will present data from recent clinical studies at our institution which have provided some important new insights regarding the mechanisms for the resolution of alveolar edema clinically. This data has also generated some important new hypotheses regarding the function of the alveolar epithelial barrier after acute lung injury.

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Authors
  1. M. A. Matthay
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1992 Springer-Verlag Berlin Heidelberg

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Matthay, M.A. (1992). The Alveolar Epithelial Barrier. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1992. Yearbook of Intensive Care and Emergency Medicine, vol 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84734-9_19

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  • DOI: https://doi.org/10.1007/978-3-642-84734-9_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55241-3

  • Online ISBN: 978-3-642-84734-9

  • eBook Packages: Springer Book Archive

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