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Delayed Consequences of Therapy

  • Chapter
Cancer in Children

Part of the book series: UICC International Union Against Cancer ((1360))

Abstract

Earlier estimates predicting that the next decade would witness such an expansion of survivors of childhood cancer that they would comprise one in every 1000 young people have now been borne out [1]. Such large numbers of young graduates (a term we now prefer to describe those children cured of an earlier childhood neoplasm) begin to force us to devise methods of providing clinical care and counselling so that the known long-term toxicities can be detected early, and patients can be advised regarding their risks. In addition, there still remain questions about the consequences of current therapy, consequences which may take many years before they become apparent. It is also necessary to distinguish between providing clinical care to patients regarding the potential long-term effect of the therapy given and the disease treated, on the one hand, and, on the other, the need to devise well-designed clinical studies that assess the probability of new toxicities whose full expression emerges only over a long period of observation. The former requires that attention be paid to individual patients, their previous disease and treatment, while the latter requires that standardized evaluations be made in every patient similarly treated with the exception of the agent being studied in order to rule out consequences of other therapies and of tumour itself.

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  1. A. T. Meadows
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  2. C. D. Burk
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  3. J. H. Silber
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Editors and Affiliations

  1. Department of Paediatric Oncology, Emma Kinderziekenhuis, Div. of Paediatrics Academic Medical Center, Meibergdreef 9, rm F8-239, 1105 AZ, Amsterdam, The Netherlands

    P. A. Voûte

  2. Department of Radiation Oncology, Beatson Oncology Centre, Western Infirmary, G11 6NT, Glasgow, UK

    Ann Barrett

  3. Service de Pédiatrie, Institut Gustave Roussy, Rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    Jean Lemerle

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Meadows, A.T., Burk, C.D., Silber, J.H. (1992). Delayed Consequences of Therapy. In: Voûte, P.A., Barrett, A., Lemerle, J. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84722-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-84722-6_8

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