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Oncogenes and Chromosomal Aberrations

  • Chapter
Cancer in Children

Part of the book series: UICC International Union Against Cancer ((1360))

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Abstract

The first chromosomal aberration associated with cancer was reported in 1960 by Nowell and Hungerford [1]. A small deleted chromosome called Philadelphia chromosome, or Ph1, was consistently found in leukaemic cells of patients with chronic myeloid leukaemia (CML). In the past 15 years the use of advanced cytogenetic techniques in studying various tumours has led to the conclusion that most cancers involve a chromosomal defect, often specific and therefore clinically relevant for diagnosis and prognosis [2, 3].

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Authors
  1. A. Hagemeijer
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  2. G. Grosveld
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Editor information

Editors and Affiliations

  1. Department of Paediatric Oncology, Emma Kinderziekenhuis, Div. of Paediatrics Academic Medical Center, Meibergdreef 9, rm F8-239, 1105 AZ, Amsterdam, The Netherlands

    P. A. Voûte

  2. Department of Radiation Oncology, Beatson Oncology Centre, Western Infirmary, G11 6NT, Glasgow, UK

    Ann Barrett

  3. Service de Pédiatrie, Institut Gustave Roussy, Rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    Jean Lemerle

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© 1992 Springer-Verlag Berlin Heidelberg

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Hagemeijer, A., Grosveld, G. (1992). Oncogenes and Chromosomal Aberrations. In: Voûte, P.A., Barrett, A., Lemerle, J. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84722-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-84722-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84724-0

  • Online ISBN: 978-3-642-84722-6

  • eBook Packages: Springer Book Archive

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