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Tumours of the Sympathetic Nervous System: Neuroblastoma, Ganglioneuroma and Phaeochromocytoma

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Cancer in Children

Part of the book series: UICC International Union Against Cancer ((1360))

Abstract

In the sympathetic nervous system three different types of tumours may arise: neuroblastoma, ganglioneuroma and phaeochromocytoma. All three originate from the same embryonic tissue and have the same anatomical sites. They vary in histology and in cytogenetics but have similar biochemistry. Their symptoms differ, and they are diagnosed and treated by different methods.

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References

  1. Coupland RE (1965) The natural history of the chromaffin cell. Longman, London

    Google ScholarĀ 

  2. Matsumura M, Tsunoda A, Nishi T, Nishihira H, 17. Sasaki Y (1991) Spontaneous regression of neuroblastoma detected by mass screening. Lancet 338: 447ā€“448

    CASĀ  Google ScholarĀ 

  3. Beckwith JB, Perrin EV (1963) In situ neuro-18. blastoma: a contribution to the natural history of neural crest tumors. Am J Pathol 43: 1089ā€“1104

    PubMedĀ  CASĀ  Google ScholarĀ 

  4. Misugi K, Misugi N, Newton WA (1968) Fine structural study of neuroblastoma, ganglioneuroblastoma and pheochromocytoma. Arch Pathol 19. Lab Med 86: 160

    CASĀ  Google ScholarĀ 

  5. Yokoyama M, Okada T, Tokue A et al. (1971) Ultrastructural and biochemical study of neuro- 20. blastoma and ganglioneuroma. Invest Urol 9: 156

    PubMedĀ  CASĀ  Google ScholarĀ 

  6. Marsden HB, Steward JK (1968) Tumours of the sympathetic system. In: Marsden HB, Steward 21. JK (eds) Tumours in children, 2nd edn. Springer, Berlin Heidelberg New York

    Google ScholarĀ 

  7. Voƻte PA (1968) Neuroblastoom, ganglio- 22. neuroom, phaeochromocytoom. Oosthoek, Utrecht

    Google ScholarĀ 

  8. Shimada H, Chatten J, Newton WA Jr, Sachs N, 23. Hamoudi Ala B, Chiba T, 4arsden HB, Misugi K (1984) Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classi- 24. fication of neuroblastomas. JNCI 73: 405417

    Google ScholarĀ 

  9. Bachmann KD (1972) Tumoren des sym- 25. pathischen Nervensystems. In: Schmid F (ed) Tumoren im Kindesalter. Springer, Berlin Heidelberg New York, p 328 (Handbuch der Kinderheilkunde 8/2)

    Google ScholarĀ 

  10. Kushner BH, Gilbert F, Helson L (1986) Familial neuroblastoma. Cancer 57: 1887

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  11. Knudson AG, Strong LC (1972) Mutation and cancer neuroblastoma and pheochromocytoma. Am J Hum Genet 24: 514

    PubMedĀ  Google ScholarĀ 

  12. Donath A, KƤser H, Roos B, Ziegler W, Oetliker O, Colombo JP, Bettex M (1965) Le PhƩochromocytome familial. Helv Paediatr Acta 20: 1

    PubMedĀ  CASĀ  Google ScholarĀ 

  13. Calkins E, Howard JE (1947) Bilateral familial pheochromocytoma with paroxysmal hyperten- 29. sion: successful surgical removal of tumors in two cases with discussion of certain diagnostic procedures and physiological considerations. J Clin Endocrinol 7: 475

    ArticleĀ  CASĀ  Google ScholarĀ 

  14. Cone TE Jr, Allen MS, Pearson HA (1957) 30. Pheochromocytoma in children: a report of three familial cases in two unrelated families. Pediatrics 19: 44

    Google ScholarĀ 

  15. Willis RA (1962) The borderland of embryology and pathology. Butterworths, London

    Google ScholarĀ 

  16. Voƻte PA, Wadman SK, Van Putten WJ (1970) Congenital neuroblastoma; symptoms in the mother during pregnancy. Clin Pediatr (Phila) 9: 206

    ArticleĀ  Google ScholarĀ 

  17. Ilda Y, Nose O, Kai H et al. (1980) Watery diarrhea with a vasoactive intestinal peptide-producing ganglioneuroblastoma. Arch Dis Child 55: 929

    ArticleĀ  Google ScholarĀ 

  18. Gustaysson S, Johansson H, Lundquist G, Nilsson F (1977) Effect of vasoactive intestinal peptide and pancreatic polypeptide on small bowel propulsion in the rat. Scand J Gastroenterol 12: 993

    ArticleĀ  Google ScholarĀ 

  19. Nickerson BG, Hutter GG (1979) Opsomyoclonus and neuroblastoma. Clin Pediatr (Phila) 18: 446

    ArticleĀ  CASĀ  Google ScholarĀ 

  20. Balakrishnan V, Simposon DA (1980) Cerebellar syndromes in occult neuroblastoma. Aust Paediatr J 16: 191ā€“193

    PubMedĀ  CASĀ  Google ScholarĀ 

  21. Pepper WA (1901) A study of congenital sarcoma of the liver and suprarenal. Am J Med Sci 121: 207

    ArticleĀ  Google ScholarĀ 

  22. Wieberdink J (1975) Foetal haemic metastases: an explanation of the Pepper type of metastases in adrenal neuroblastoma. Br J Cancer 11: 378

    ArticleĀ  Google ScholarĀ 

  23. Anders D, Kindermann G, Pfeiffer U (1973) Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis. J Pediatr 82: 50

    ArticleĀ  Google ScholarĀ 

  24. Van der Slikke JW, Balk AG (1980) Hydramnios and hydrops fetalis and disseminated fetal neuro-blastoma. Obstet Gynecol 55 /2: 250

    PubMedĀ  Google ScholarĀ 

  25. Hutchison R (1907) On suprarenal sarcoma in children with metastases in the skull. Q J Med 1: 33

    Google ScholarĀ 

  26. Tchernia G, Vieu F, Parmentier C, Schweisguth O (1974) Lā€™anĆ©mie au cours du neuroblastome chez lā€™enfant. Nouv Rev Fr Hematol 14: 45

    Google ScholarĀ 

  27. Gitlow SE, Bertani LM, Greenwood SM, Wong BL, Dziedzic SW (1972) Benign pheochromocytoma associated with elevated excretion of homovanillic acid. J Pediatr 81: 1112

    Google ScholarĀ 

  28. VoĆ»te PA, Vos A, Delemarre JFM, De Kraker J, Burgers JMV, Van Dobbenburgh OA (1980) The persistent challenge of neuroblastoma. In: van Eys J, Sullivan MP (eds) Status of the curability of childhood cancers. Raven, New York, p 145ā€“161

    Google ScholarĀ 

  29. Gitlow SE, Bertani LM, Rausen A, Gribetz D, Dziedzic SW (1970) Diagnosis of neuroblastoma by qualitative and quantitative determination of catecholamine metabolities in urine. Cancer 25: 1377

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  30. Rajnherc JR, Van Gennip AH, Abeling NGGM, Van der Zee JM, VoĆ»te PA (1984) Cystathioninuria in patients with neuroblastoma. Med Pediatr Oncol 12: 81ā€“84

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  31. Zeltzer PM, Marangos PJ, Satter H, Evans A, Siegel S, Wong KY, Dalton A, Seeger R, Hammond D (1985) Prognostic importance of serum neuron specific enolase in local and widespread neuroblastoma. In: Evans AE, Dā€™Angio GJ, Seeger RC (eds) Advances in neuroblastoma research. Liss, New York, p 319

    Google ScholarĀ 

  32. Hann HL, Stahlhut MW, Evans AE (1985) Serum ferritin as a prognostic indicator in neuro-blastoma: biological effects of isoferritins. In: Evans AE, Dā€™Angio GJ, Seeger RC (eds) Advances in neuroblastoma research. Liss, New York, p 331

    Google ScholarĀ 

  33. Hann HL, Stahlhut MW, Evans AE (1988) Basic and acidic iso ferritins in the sera of patients with neuroblastoma. Cancer 62: 1179

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  34. Silber JH, Evans AE, Fridman M (1991) Models to predict outcome from childhood neuro-blastoma: the role of serum ferritin and tumor histology. Cancer Res 51: 1426ā€“1433

    PubMedĀ  CASĀ  Google ScholarĀ 

  35. Seeger RC, Brodeur GM, Sather H et al. (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313: 111ā€“116

    ArticleĀ  Google ScholarĀ 

  36. Bourhis J, De Vathaire F, Wilson GD, Hartmann O, Terrier-Lacombe MJ, BocconGibod L, McNally NJ, Lemerle J, Riou G, BĆ©nard J (1991) Combined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma. Cancer Res 51: 33ā€“36

    PubMedĀ  CASĀ  Google ScholarĀ 

  37. Look T, Hays FA, Shuster JJ, Douglass EC, Castleberry RP, Bowman LC, Smith EI, Brodeur GM (1991) Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol 9 /4: 581ā€“591

    PubMedĀ  CASĀ  Google ScholarĀ 

  38. Martinsson T, Weith A, Cziepluch C, Schwab M (1989) Chromosome I deletions in human neuroblastomas: generation and fine mapping of microclones from the distal 1p region. Genes Chromosomes Cancer 1: 67ā€“78

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  39. Weith A, Martinsson T, Cziepluch C, BrĆ¼derlein S, Amler LC, Berthold F, Schwab M (1989) Neuroblastoma consensus deletion maps to 1p36.1ā€“2. Genes Chromosomes Cancer 1: 159ā€“166

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  40. Kimmig B, Brandeis WE, Adolph J (1985) Diagnose und Therapiekontrolle des Neuroblastoms mit meta-Jod-Benzylguanidin. Dtsch Med Wochenschr 110: 175ā€“179

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  41. Hoefnagel CA (1989) The clinical use of 131Imeta-iodobenzylguanidine ( MIBG) for the diagnosis and treatment of neural crest tumors. University of Amsterdam p 100

    Google ScholarĀ 

  42. Schweisguth O (1979) Tumeur de la crĆŖte neurale. In: Schweisguth O (ed) Tumeurs solides de lā€™enfant. Flammarion, Paris

    Google ScholarĀ 

  43. UICC (1985) TNM-atlas, illustrated guide to the TNM/pTNM classification of malignant tumours, 2nd edn. UICC, Geneva

    Google ScholarĀ 

  44. Evans AE, Dā€™Angio GJ, Randolph J (1971) A proposed staging for children with neuro-blastoma: Childrenā€™s Cancer Study Group A. Cancer 27: 374ā€“378

    Google ScholarĀ 

  45. Rubie H, Hartmann O, Giron A, Lemoine G, Gruner M, Brugieres L, Valteau-Couanet D, Robert A, Lemerle J (1991) Nonmetastatic thoracic neuroblastoma: a review of 40 cases. Med Pediatr Oncol 19: 253ā€“257

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  46. Pellerin D, Nihoul-FƩkƩtƩ, RƩvillon Y, Fernandes P (1982) Place of surgery in neuro-blastoma. In: Raybaud C, ClƩment R, Lebreuil G, Bernard JL (eds) Pediatric oncology. Excerpta Medica, Amsterdam, p 131 (International congress series, vol 570 )

    Google ScholarĀ 

  47. Koop CE (1968) Neuroblastoma: two year survival and treatment correlations. J Pediatr Surg 3: 178

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  48. VoĆ»te PA, Hoefnagel CA, De Kraker J, Valdes Olmos R, Bakker DJ, Van de Kleij AJ (1991) Results of treatment with 131 Imetaiodobenzylguanidine (131 I-MIBG) in patients with neuroblastoma. Future prospects of zetotherapy. In: Evans AE, Dā€™Angio GJ, Knudson AG Jr, Seeger RC (eds) Advances in neuroblastoma research, vol 3. Wiley-Liss, New York, pp 439ā€“445

    Google ScholarĀ 

  49. Oā€™Donoghue JA, Wheldon TE, Babich JW, Moyes JSE, Barrett A, Metier ST (1991) Therapeutic implications of the uptake of radiolabelled MIBG for the treatment of neuroblastoma. In: Evans AE, Dā€™Angio GJ, Knudson AG Jr, Seeger RC (eds) Advances in neuroblastoma research, vol 3 Wiley-Liss, New York, pp 455ā€“461

    Google ScholarĀ 

  50. Green AA, Hayes FA, Hustur HO (1981) Sequential cyclophosphamide and doxorubicin for induction of complete remission in children with disseminated neuroblastoma. Cancer 48 /10: 2310ā€“2317

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  51. Bernstein ID, Evans EA, Finklestein J, Klemperer M, Hittle R, Leikin S, Hammond GD (1978) Phase II study of the failure of vincristine and bleomycin for previously treated children with metastatic neuroblastoma: a report from the Childrenā€™s Cancer Study Group. Cancer Treat Rep 62 /8: 1201

    PubMedĀ  CASĀ  Google ScholarĀ 

  52. Leikin S, Bernstein I, Evans E (1975) Use of combination Adriamycin (NSC-123127) and DTIC (NSC-45388) in children with advanced stage IV neuroblastoma. Cancer Chemother Rep 59: 1015ā€“1018

    PubMedĀ  CASĀ  Google ScholarĀ 

  53. Finklestein JZ, Klemperer MR, Evans A, Bernstein I, Leikin S, McCreadie S, Grosfeld J, Hittle R, Weiner J, Sather H, Hammond D (1979) Multiagent chemotherapy for children with metastatic neuroblastoma: a report from the Childrenā€™s Cancer Study Group. Med Pediatr Oncol 6: 179ā€“188

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  54. Shafford EZ, Rogers DW, Pritchard J (1984) Advanced neuroblastoma: improved response rate using a multiagent regimen (OPEC) including sequential cisplatin and VM-26. J Clin Oncol 2: 742ā€“747

    PubMedĀ  CASĀ  Google ScholarĀ 

  55. Pinkerton CR, Pritchard J, De Kraker J, Jones DR, Germond S (1987) ENSG 1-randomized study of high dose melphalan in neuroblastoma. In: Dicke KA, Spitzer G, Jagannath S (eds) Autologous bone marrow transplantation.University of Texas Press, Houston, pp 401ā€“410

    Google ScholarĀ 

  56. Philip T, Zucker JM, Bernard JL, Lutz P,Bordigoni P, Plouvier E, Robert A, RochĆ© H,Souillet G, Bouffet E, Michon J, Lopez M, Vilcoq JM, Gentet JC, Philip I, LadensteinR, Favrot M, Chauvin F (1991) Improved survival at 2 and 5 years in the LMCE1 unselected group of 72 children with stage IV neuroblastoma older than 1 year of age at diagnosis: is cure possible in a small subgroup? J Clin Oncol 9 /6: 1037ā€“1044.

    PubMedĀ  CASĀ  Google ScholarĀ 

  57. Dini G, Lanino E, Garaventa A, Rogers D, Dallorso S, Viscoli C, Castagnola E, Manno G,Brisigotti M, Rosando C, Pasino M, Rivabella L, Boni L, Marchese N, Ivani G, Rizzo A, Franzone P, Trasino S, De Bernardi B (1991) Myeloablative therapy and unpurged autologous bone marrow transplantation for poor-prognosis neuroblastoma: report of 34 cases. J Clin Oncol 9 /6: 962ā€“969

    PubMedĀ  CASĀ  Google ScholarĀ 

  58. Goldstein LJ, Fojo AT, Ueda K, Crist W, Green A, Brodeur G, Pastan I, Gottesman MM (1990) Expression of the multidrug resistance, MDR1,gene in neuroblastomas. J Clin Oncol 8 /1: 128ā€“136

    PubMedĀ  CASĀ  Google ScholarĀ 

  59. Figdor CG, Bont WS, De Vries JE, Van Es WL (1981) Isolation of large numbers of highly purified lymphocytes and monocytes with a modified centrifugal technique. J Immunol Methods 40: 275

    ArticleĀ  PubMedĀ  CASĀ  Google ScholarĀ 

  60. Kemshead JT, Treleaven JG, Gibson FM, Ugelstad J, Rembaum A, Philip T, Caine GD (1984) Removal of neuroblastoma cells from bone marrow with monoclonal antibodies con-jugated to magnetic microspheres. Lancet 1: 70ā€“73

    PubMedĀ  Google ScholarĀ 

  61. Seeger RC, Siegel SE, Sidell N (1982) Neuro-blastoma: clinical perspectives, monoclonal antibodies, and retinoic acid. Ann Intern Med 97: 873ā€“884

    PubMedĀ  CASĀ  Google ScholarĀ 

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Ā© 1992 Springer-Verlag Berlin Heidelberg

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Voƻte, P.A., de Kraker, J., Hoefnagel, C.A. (1992). Tumours of the Sympathetic Nervous System: Neuroblastoma, Ganglioneuroma and Phaeochromocytoma. In: Voƻte, P.A., Barrett, A., Lemerle, J. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84722-6_19

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  • DOI: https://doi.org/10.1007/978-3-642-84722-6_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84724-0

  • Online ISBN: 978-3-642-84722-6

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