Skip to main content

Germ Cell Tumours

  • Chapter
Cancer in Children

Part of the book series: UICC International Union Against Cancer ((1360))

  • 112 Accesses

Abstract

Germ cell tumours are uncommon, with an incidence of approximately 3 per 100 person years [1]. They may be benign or malignant. Benign tumours are commoner, but their exact incidence is more difficult to ascertain because of incomplete notification to tumour registries.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Birch JM, Marsden HB, Morris Jones PH, Pearson D, Blair V (1988) Improvements in survival from childhood cancer: results of a population based survery over 30 years. Br Med J 296: 1372–1376

    Article  CAS  Google Scholar 

  2. Mann JR, Pearson D, Barrett A, Raafat F, Barnes JM, Wallendszus KR (1989) Results of the United Kingdom Children’s Cancer Study Group’s malignant germ cell tumour studies. Cancer 63: 1657–1667

    Article  PubMed  CAS  Google Scholar 

  3. Brown NJ (1976) Teratomas and yolk-sac tumours. J Clin Pathol 29: 1021–1025

    Article  PubMed  CAS  Google Scholar 

  4. Thakray AC (1964) Seminoma. In: Collins DH, Pugh RCB (eds) The pathology of testicular tumours. Churchill Livingstone, Edinburgh, pp 12–27

    Google Scholar 

  5. Birch JM, Marsden HB, Swindell R (1982) Prenatal factors in the origin of germ cell tumours of childhood. Carcinogenesis 1: 75–80

    Article  Google Scholar 

  6. Taylor H, Barter RH, Jacobson CB (1966) Neoplasms of dysgenetic gonads. Am J Obstet Gynecol 96: 816–823

    PubMed  CAS  Google Scholar 

  7. Marsden HB, Birch JM, Swindell R (1981) Germ cell tumours of childhood: a review of 137 cases. J Clin Pathol 34: 879–883

    Article  PubMed  CAS  Google Scholar 

  8. Li FP, Fraumeni JF (1972) Testicular cancers in children: epidemiologic characteristics. JNCI 48: 1575–1582

    PubMed  CAS  Google Scholar 

  9. Dehner LP (1986) Gonadal and extragonadal germ cell neoplasms — teratomas in childhood. In: Finegold M, Benington JL (eds) Pathology of neoplasia in children and adolescents. Major problems in pathology. Saunders, Philadelphia, pp 282–312

    Google Scholar 

  10. Brodeur GM, Howarth CB, Pratt CB, Caces J, Hustu HO (1981) Malignant germ cell tumours in 57 children and adolescents. Cancer 48: 1890–1898

    Article  PubMed  CAS  Google Scholar 

  11. Elwood JM, Elwood JH (1980) Epidemiology of anencephalus and spina bifida. Oxford University Press, Oxford, pp 255–267

    Google Scholar 

  12. Horwich A, Peckham M (1984) Serum tumour marker regression rate following chemotherapy for malignant teratoma. Eur J Cancer Clin Oncol 20: 1463–1470

    Article  PubMed  CAS  Google Scholar 

  13. Green DM (1983) The diagnosis and treatment of yolk sac tumors in infants and children. Cancer Treat Rev 10: 265–288

    Article  PubMed  CAS  Google Scholar 

  14. Rogers P, Pritchard J, Pincott JR, Spitz L (1988) Sacrococcygeal teratoma (ST): review and management of 34 infants. Proceedings of the 7th annual meeting of the American Society of Clinical Oncology, 30 April-2 May, vol 22, p 407 (abstr C-293)

    Google Scholar 

  15. Ein SH, Adeyeimi SD, Mancer K (1980) Benign sacrococcygeal teratomas in infants and children, A 25 year review. Ann Surg 191: 382–384

    Article  PubMed  CAS  Google Scholar 

  16. Gross RE, Clatworthy HW Jr, Meeker IA (1981) Sacrococcygeal teratomas in infants and children, A report of 40 cases. Surg Gynecol Obstet 92: 341–354

    Google Scholar 

  17. Kersh CR, Constable WC, Eisert DR, Spaulding CA, Hahn SS, Jenrette JM, Marks RD (1988) Primary central nervous system germ cell tumors, Effect of histologic confirmation on radiotherapy. Cancer 61: 2148–2152

    Article  PubMed  CAS  Google Scholar 

  18. Legido A, Packer RJ, Sutton LN, D’Angio G, Rorke LB, Bruce DA, Schut L (1989) Supra-sellar germinomas in childhood. Cancer 63: 340–344

    Article  PubMed  CAS  Google Scholar 

  19. Tait D, Peckham MJ, Hendry WF, Goldstraw P (1984) Post-chemotherapy surgery in advanced non-seminomatous germ-cell testicular tumours: the significance of histology with particular reference to differentiated (mature) teratoma. Br J Cancer 50: 601–609

    Article  PubMed  CAS  Google Scholar 

  20. Gobel U, Calaminus G, Haas HJ, Jurgens H, Niethammer D, Ritter J, Spaar HJ, Harms D (1987) Strategy and treatment results of a co-operative trial for non-testicular germ cell tumors (GCT’s) of the German Society of Pediatric Oncology (GPO) (MAKEI 83/86). Med Pediatr Oncol 15: 306

    Google Scholar 

  21. Bloom HJG (1983) Primary intracranial germ cell tumours. J Clin Oncol 2: 233–257

    Google Scholar 

  22. Ablin A, Krailo M, Ramsay N, Isaacs H, Raney B, Adkins J, Hays D, Leikin S, Benjamin D, and Hammond D (1987) Biologic characteristics and response to therapy in 89 patients with malignant germ cell tumours (MGCT): a Children’s Cancer Group ( CCG) study. Med Pediatr Oncol 15: 294

    Google Scholar 

  23. Etcubanas E, Thompson E, Jenkins J, Rao B, Brodeur G, Hustu O, Kun L, Green A (1987) Clinical management of childhood malignant germ cell tumors. Med Pediatr Oncol 15: 305–306

    Google Scholar 

  24. Flamant F, Hartmann O, Kalifa C, Patte C, Caillaud JM, Lemerle J (1987) Review of a series of 82 non-seminomatous germ cell tumors (nsGCT) treated at the same center between 1978 and 1984. Med Pediatr Oncol 15: 307

    Google Scholar 

  25. Homsy Y, Arrojo-Villa F, Khoriaty N, Demers J (1984) Yolk sac tumor of the testicle: is retroperitoneal lymph node dissection necessary? J Urol 132: 532–536

    PubMed  CAS  Google Scholar 

  26. Kurman RJ, Norris HJ (1978) Germ cell tumors of the ovary. Hum Pathol 1: 291–325

    Google Scholar 

  27. Slayton RE (1984) Management of germ cell and stromal tumors of the ovary. Semin Oncol 11: 299–313

    PubMed  CAS  Google Scholar 

  28. Gallion H, Van Nagell JR, Jr, Powell DF et al. (1979) Therapy of endodermal sinus tumour of the ovary. Am J Obstet Gynecol 135: 477–451

    Google Scholar 

  29. Green DM, Brecher ML, Grossi M, Simpson L, Fisher J, Allan J, Cooney DR, Jewett TC Jr, Freeman AI (1983) The use of different induction and maintenance chemotherapy regimens for the treatment of advanced yolk sac tumors. J Clin Oncol 1: 111–116

    PubMed  CAS  Google Scholar 

  30. Young RJ, Scully RE (1984) Endodermal sinus tumor of the vagina: a report of nine cases and review of the literature. Gynecol Oncol 18: 380–392

    Article  PubMed  CAS  Google Scholar 

  31. Leverger G, Flamant F, Gerboulet A, Lemerle J (1983) Tumeurs du sac vitellin de localisation vaginale chez l’enfant (à propos de 11 cas). Arch Fr Pediatr 40: 85–89

    PubMed  CAS  Google Scholar 

  32. de Tribolet N, Barrelet L (1977) Successful chemotherapy of pinealoma. Lancet 2: 1228–1229

    Article  PubMed  Google Scholar 

  33. Packer RJ, Sutton LN, Rosenstock JG, Rorke LB, Bilaniuk LT, Zimmerman RA, Littman PA, Bruce DA, Schut L (1984) Pineal region tumors of childhood. Pediat 74: 97–102

    CAS  Google Scholar 

  34. Wara WM, Jenkin DT, Evans A et al. (1979) Tumours of the pineal and suprasellar region: Children’s Cancer Study Group treatment results 1960–1975. Cancer 43: 698–701

    Article  PubMed  CAS  Google Scholar 

  35. Lack EE, Weinstein HJ, Welch KJ (1985) Mediastinal germ cell tumours in childhood. A clinical and pathologic study of 21 cases. J Thorac Cardiovasc Surg 89: 829–835

    Google Scholar 

  36. Dehner LP (1983) Gonadal and extragonadal germ cell neoplasia of childhood. Hum Pathol 14: 493–511

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Barrett, A., Mann, J.R. (1992). Germ Cell Tumours. In: Voûte, P.A., Barrett, A., Lemerle, J. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84722-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84722-6_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84724-0

  • Online ISBN: 978-3-642-84722-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics