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Hodgkin’s Disease

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Cancer in Children

Part of the book series: UICC International Union Against Cancer ((1360))

Abstract

While the aetiology of Hodgkin’s disease remains unknown, the biology of the disease confirms neoplastic behaviour. Cytogenetic studies suggest that the Reed-Sternberg cells, for which this disease was originally named, represent the malignant cells in Hodgkin’s disease. Most authorities believe that this cell is lymphocytic in origin, coming from activated B- or T-lymphocytes. It appears that the Hodgkin’s cell is derived from an immature lymphoid stage of differentiation prior to or during B- or T-cell receptor gene rearrangement [1]. There are many possible sources of transformation in Hodgkin’s cells, including cytogenetic abnormalities, evidence for proto-oncogene involvement and Epstein-Barr virus infection and/or activation. The heterogeneity of the clinical and histological appearance of Hodgkin’s disease and the multitude of different and controversial cellular markers might be explained by the theory that Hodgkin’s disease is a group of aetio-pathophysiologically associated but not identical disease entities.

This research was supported in part by grant CA-34233 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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Authors
  1. S. S. Donaldson
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  2. O. Oberlin
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Editors and Affiliations

  1. Department of Paediatric Oncology, Emma Kinderziekenhuis, Div. of Paediatrics Academic Medical Center, Meibergdreef 9, rm F8-239, 1105 AZ, Amsterdam, The Netherlands

    P. A. Voûte

  2. Department of Radiation Oncology, Beatson Oncology Centre, Western Infirmary, G11 6NT, Glasgow, UK

    Ann Barrett

  3. Service de Pédiatrie, Institut Gustave Roussy, Rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    Jean Lemerle

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Donaldson, S.S., Oberlin, O. (1992). Hodgkin’s Disease. In: Voûte, P.A., Barrett, A., Lemerle, J. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84722-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-84722-6_14

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