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Acute Myeloid Leukaemia

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Cancer in Children

Part of the book series: UICC International Union Against Cancer ((1360))

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Abstract

Although less frequent than acute lymphoblastic leukaemia (ALL) the incidence of acute myeloid leukaemia (AML) is still significant, constituting approximately 20% of childhood acute leukaemia cases in large series [1]. Compared with childhood ALL, the treatment of AML is less satisfactory because of (a) lower remission rate, (b) lower percentage of long-term survivors and (c) greater need for supportive measures to combat infection and haemorrhage during initial induction therapy. Bone marrow transplantation (BMT) during first remission may also have a more important role in AML than in ALL. Children and adolescents with all types of leukaemia should be treated at specialized centres since research is still needed before the biology and treatment of all types can be understood. Patients with AML in particular should be referred to specialized centres since the treatment is complicated, and results are superior at such centres.

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Authors
  1. M. L. N. Willoughby
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  2. B. Lampkin
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Editors and Affiliations

  1. Department of Paediatric Oncology, Emma Kinderziekenhuis, Div. of Paediatrics Academic Medical Center, Meibergdreef 9, rm F8-239, 1105 AZ, Amsterdam, The Netherlands

    P. A. Voûte

  2. Department of Radiation Oncology, Beatson Oncology Centre, Western Infirmary, G11 6NT, Glasgow, UK

    Ann Barrett

  3. Service de Pédiatrie, Institut Gustave Roussy, Rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    Jean Lemerle

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Willoughby, M.L.N., Lampkin, B. (1992). Acute Myeloid Leukaemia. In: Voûte, P.A., Barrett, A., Lemerle, J. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84722-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-84722-6_10

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