Abstract
Apolipoprotein E (apoE) is atypical of the other plasma apolipoproteins in that it is synthesized in a wide variety of peripheral tissues and in diverse cell types and not just in liver and small intestine (Blue et al.1983; Williams et al.1985b). Although considerable information about the regulation of apoE expression in various cell types has accumulated over the past decade, little is known about the function of apoE that is synthesized locally in many tissues. Among the potential functions in lipid metabolism that have been suggested are 1) a role in reverse cholesterol transport to target interstitial lipoproteins for hepatic clearance, 2) as a component of a local mechanism for removing cholesterol from cells or shuttling lipid between cells in a tissue, 3) as a means to enhance targeting of lipoproteins for uptake by cells expressing apoE, and 4) as a regulator of intracellular cholesterol utilization (Blueet al.1983; Williams et al.1985b; Williams et al.1985a). ApoE may also have autocrine or paracrine activities not directly related to lipid metabolism since apoE can modify hormonal or mitogenic stimuli in ovarian theca/interstitial cells and T lymphocytes, respectively (Dyer & Curtiss, 1988; Curtiss et al.1977).
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© 1993 Springer-Verlag Berlin Heidelberg
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Williams, D.L., Prack, M.M., Nicosia, M., Gwynne, J.T., Reyland, M.E. (1993). Analysis of Apolipoprotein E Function in Adrenal Cells: Effects on Cholesterol Metabolism and Signal Transduction Pathways. In: Sirtori, C.R., Franceschini, G., Brewer, B.H. (eds) Human Apolipoprotein Mutants III. NATO ASI Series, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84634-2_9
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DOI: https://doi.org/10.1007/978-3-642-84634-2_9
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