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Identification of Common Genetic Polymorphisms that Determine Plasma Levels of ApoAI and HDL-C

  • Steve Humphries
  • Vilmundur Gudnason
  • Hiroko Paul-Hayase
  • N. Saha
  • Maryvonne Rosseneu
Part of the NATO ASI Series book series (volume 73)

Abstract

A large number of epidemiological studies have demonstrated that low serum levels of high density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (apo AI) are risk factors for the development of coronary artery disease (CAD). Various environmental factors including exogenous gonadal steroids, alcohol intake, stress, infection, the amount of exercise and some drug therapy can significantly affect plasma HDL-C levels. However, there is also good evidence for the involvement of genetic variation in determining these traits, and the heritability of HDL-C and apo AI has been estimated in various studies to be between 0.43 and 0.66 (Hamsten et al 1986). Recently, evidence for a major gene determining individual differences in quantitative levels of apo AI was demonstrated in a population-based sample by applying biometrical techniques (Moll et al 1989).

Keywords

High Density Lipoprotein Cholesterol Cholesteryl Ester Transfer Protein High Density Lipoprotein Cholesterol Level High Density Lipoprotein Cholesterol Concentration APOAI Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Steve Humphries
    • 1
  • Vilmundur Gudnason
    • 1
  • Hiroko Paul-Hayase
    • 1
  • N. Saha
    • 3
  • Maryvonne Rosseneu
    • 2
  1. 1.Centre for the Genetics of Cardiovascular Disorders, Rayne InstituteUniversity College HospitalLondonUK
  2. 2.Clinical ChemistryA-Z St JanBelgium
  3. 3.Department of physiology, Faculty of MedicineNational University of SingaporeKent RidgeSingapore

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