Calcium Regulation of Ion Channels in Neurons

  • Robert S. Zucker
Conference paper
Part of the NATO ASI Series book series (volume 60)


Intracellular calcium modulates the activity of a number of voltage-dependent ion channels in neurons. This modulation is often functionally important, and can influence the responsiveness of cells to natural inputs. In extreme cases, the regulation of ion channels by intracellular calcium can even determine the pattern of electrical activity of neurons. In this review, I will summarize the role of calcium in electrogenesis in bursting molluscan neurons, and in responses to synaptic inputs in rat hippocampal cells and frog sympathetic ganglion neurons.


Calcium Current Potassium Current Pacemaker Current Nonspecific Cation Nonspecific Cation Channel 
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  1. Adams PR, Brown DA (1982) Synaptic inhibition of the M-current: slow excitatory post-synaptic potential mechanism in bullfrog sympathetic neurones. J Physiol (Lond) 332: 263–272Google Scholar
  2. Adams SR, Kao JPY, Grynkiewicz G, Minta A, Tsien RY (1988) Biologically useful chelators that release Ca2+ upon illumination. J Am Chem Soc 110: 3212–3220CrossRefGoogle Scholar
  3. Adams SR, Kao JPY, Tsien RY (1989) Biologically useful chelators that take up Ca2+ upon illumination. J Amer Chem Soc 111: 7957–7968CrossRefGoogle Scholar
  4. Adams WB (1985) Slow depolarizing and hyperpolarizing currents which mediate bursting in Aplysia neurone R15. J Physiol (Lond) 360: 51–68Google Scholar
  5. Adams WB, Levitan IB (1985) Voltage and ion dependences of the slow currents which mediate bursting in Aplysia neurone R15. J Physiol (Lond) 360: 69–93Google Scholar
  6. Delaney KR, Zucker RS (1990) Calcium released by photolysis of DM-nitrophen stimulates transmitter release at squid giant synapse. J Physiol 426: 473–498PubMedGoogle Scholar
  7. Eckert R, Chad JE (1984) Inactivation of Ca channels. Prog Biophys Molec Biol 44: 215–267CrossRefGoogle Scholar
  8. Fryer MW, Zucker RS (1990) Photolysis of theaged Ca2+ chelator diazo-4 rapidly decreases Ca2+ accumulation and Ca2+ channel inactivation in Aplysia neurones. Soc Neurosci Abs 16: 1171Google Scholar
  9. Gorman ALF, Hermann A, Thomas MV (1982) Ionic requirements for membrane oscillations and their dependence on the calcium concentration in a molluscan bursting pace-maker neurone. J Physiol (Lond) 327: 185–217Google Scholar
  10. Gorman ALF, Thomas MV (1980) Potassium conductance and internal calcium accumulation in a molluscan neurone. J Physiol (Lond) 308: 287–313Google Scholar
  11. Gurney AM, Tsien RY, Lester HA (1987) Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons. Proc Nat Acad Sci USA 84: 3496–3500PubMedCrossRefGoogle Scholar
  12. Jan LY, Jan YN (1982) Peptidergic transmission in sympathetic ganglia of the frog. J Physiol 327: 219–246PubMedGoogle Scholar
  13. Johnson BD, Byerly WL (1990) Control of neuronal calcium current by intracellular calcium. Soc Neurosci Abs 16: 1173Google Scholar
  14. Kramer RH, Zucker RS (1985) Calcium-dependent inward current in Aplysia bursting pacemaker neurones. J Physiol (Lond) 362: 107–130Google Scholar
  15. Kramer, RH & Zucker, RS (1985) Calcium-induced inactivation of calcium current causes the inter-burst hyperpolarization of Aplysia bursting neurones. J Physiol (Lond) 362: 131–160Google Scholar
  16. Kuffler SW, Sejnowski TJ (1983) Peptidergic and muscarinic excitation at amphibian sympathetic synapses. J Physiol (Lond) 341: 257–278Google Scholar
  17. Lancaster B, Adams PR (1986) Calcium-dependent current generating the afterhyperpolarization of hippocampal neurons. J Neurophysiol 55: 1268–1281PubMedGoogle Scholar
  18. Lancaster, B & Nicoll, RA (1987) Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J Physiol (Lond) 389: 187–203Google Scholar
  19. Landò L, Zucker RS (1989) “Caged calcium” in Aplysia pacemaker neurons. Characterization of calcium-activated potassium and nonspecific cation currents. J Gen Physiol 93: 1017–1060PubMedCrossRefGoogle Scholar
  20. Marrion NV, Zucker RS, Marsh SJ, & Adams PR (1991) Modulation of M-current by intracellular calcium. Neuron, in pressGoogle Scholar
  21. Muller, TH, Swandulla, D, & Lux, HD (1989) Activation of three types of membrane currents by various divalent cations in identified molluscan pacemaker neurons. J Gen Physiol 94: 997–1014PubMedCrossRefGoogle Scholar
  22. Pfaffinger PJ, Leibowitz MD, Subers EM, Nathanson NM, Almers W, Hille B (1988) Agonists that suppress M-current elicit phosphoinositide turnover and Cat+ transients, but these do not explain M-current suppression. Neuron 1: 477–484PubMedCrossRefGoogle Scholar
  23. Storm JF (1989) An after-hyperpolarization of medium duration in rat hippocampal pyramidal cells. J Physiol (Lond) 449: 171–190Google Scholar
  24. Swandulla D, Lux HD 1985 ) Activation of a nonspecific cation conductance by intracellular Ca2+ elevation in bursting pacemaker neurons of Helix pomatia. J Neurophysiol 54: 1430–1443PubMedGoogle Scholar
  25. Thompson S, Smith SJ, Johnson JW (1986) Slow outward tail currents in molluscan bursting pacemaker neurons: two components differing in temperature sensitivity. J Neurosci 6: 3169–3176PubMedGoogle Scholar
  26. Tsien R, Zucker RS (1986) Control of cytoplasmic calcium with photolabile 2-nitrobenzhydrol tetracarboxylate chelators. Biophys J 50: 843–853PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Robert S. Zucker
    • 1
  1. 1.Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA

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