ATP-Sensitive K+ Channels : Molecular Pharmacology, Regulation and Role in Diseased States

  • M. Lazdunski
  • M. Fosset
  • J. De Weille
  • E. Honoré
  • C. Mourre
Conference paper
Part of the NATO ASI Series book series (volume 60)

Abstract

ATP-dependent K+ (KATP) channels have now been identified in many tissues including β-cells, cardiac cells, skeletal muscle cells and neurons (reviewed in.l). They are the targets of 2 important classes of drugs, the antidiabetic sulfonylureas (2,3), which block the channel, and a series of compounds called K+ channel openers (24,25) and which include cromakalim, pinacidil, nicorandil, minoxidil sulfate, and RP 49356, which tend to maintain the channel in an open conformation. The activity of KATP channels is regulated by the ATP/ADP ratio. ATP or ADP alone inhibit the KATP channel. However, in the presence of ATP, ADP-Mg2+ activates the channel (see for example 6). The KATP channel is an excellent reporter of intracellular variations of the ATP/ADP ratio and has been used to demonstrate the presence of Cl channels essential for oxydative phosphorylation in mitochondria (7)

Keywords

Ischemia Hyperglycemia Pertussis Noma Sulfonylurea 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • M. Lazdunski
    • 1
  • M. Fosset
    • 1
  • J. De Weille
    • 1
  • E. Honoré
    • 1
  • C. Mourre
    • 1
  1. 1.Institut de Pharmacologie Moléculaire et CellulaireUPR 0411 du CNRSValbonneFrance

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