Physiological functions of vacuoles in yeast: Mechanism of sequestration of metabolites and proteins into vacuoles
Vacuoles are the largest compartment in yeast cells, occupying about 25% of the total cell volumes. Vacuoles contain mainly low molecular weight solutes and ions, but quite small amount of proteins. Recent studies revealed that vacuoles are not inert organelles as previously thought, but play important roles on maintaining homeostasis of cytosol in many respects. Last 15 years we have been making efforts to understand the structure and function of vacuoles in yeast, Saccharomyces cerevisiae, by taking several different approaches, as described below.
KeywordsPolysaccharide Serine Lysine Arginine Fructose
Unable to display preview. Download preview PDF.
- Henomatsu N, Yoshimori T, Moriyama Y, Futai M, Tashiro Y (1990) Effect of Bafilomycin A1 on intracellular distribution of prolactin in the GH3 rat pituitary tumor cells. Cell Struct. Funct. 15:447.Google Scholar
- Matile P (1975) The lytic compartment of plant cells. Cell Biology Monographs, Vol. 1, Springer-Verlag, Wien, New York.Google Scholar
- Ohsumi Y, Anraku Y (1985) Specific induction of Ca2+ transport activity in MATa cells of Saccharomyces cerevisiae by a mating pheromone a factor. J. Biol. Chem. 269:10482–10486.Google Scholar