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Frozen Haplotypes in Mhc Evolution

  • Jan Klein
  • Colm O’hUigin
  • Masanori Kasahara
  • Vladimir Vincek
  • Dagmar Klein
  • Felipe Figueroa
Part of the NATO ASI Series book series (volume 59)

Abstract

An odd feature of the HLA-DRB region is its remarkable haplotype polymorphism: At least five groups of haplotypes differing both in length and in number of genes exist in the human population at appreciable frequencies. We have demonstrated that similar DRB haplotype polymorphism exists also in the apes - the chimpanzee and the gorilla. Moreover, certain haplotype segments have apparently remained intact since the human-chimpanzee (gorilla) divergence more than five million years ago. Hence, not only allelic but also haplotype polymorphisms evolve trans-specifically at the DRB region. The evolutionary origins of the individual haplotype groups and the possible reasons for the extreme linkage disequilibrium between certain DRB genes (the frozen haplotypes) are discussed.

Keywords

Major Histocompatibility Complex Restriction Fragment Length Polymorphism Analysis Major Haplotype Human Major Histocompatibility Complex Haplotype Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Jan Klein
    • 1
    • 2
  • Colm O’hUigin
    • 1
  • Masanori Kasahara
    • 2
  • Vladimir Vincek
    • 2
  • Dagmar Klein
    • 2
  • Felipe Figueroa
    • 1
  1. 1.Abteilung ImmungenetikMax-Planck-Institut für BiologieTübingenGermany
  2. 2.Department of Microbiology and ImmunologyUniversity of Miami School of MedicineMiamiUSA

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