Swelling from the Perspective of Molecular Assemblies and Single Functioning Biomolecules

  • V. Adrian Parsegian
  • R. Peter Rand
  • Donald C. Rau
Conference paper
Part of the NATO ASI Series book series (volume 64)

Abstract

Given the origins of life in an aqueous milieu and the importance of the internal aqueous environment, it is no surprise that the hydration and swelling of biomolecules is a central feature of their organization and function. Through direct measurement of intermolecular forces in aqueous solutions, we have come to recognize new ways in which nature achieves the controlled swelling essential to living matter. In this paper we will outline how we see that nature may make use of similar hydration/dehydration energetics in controlling single-molecular kinetics as she does in controlling molecular assembly. We summarize what seem to be universal principal features of hydration. In many different kinds of systems these features allow us to see how the swelling energetics of living matter not only compares with that in inanimate systems but also can be quantitatively probed with great sensitivity by using osmotic stress.

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References

  1. Benz, R., Ludwig, O., de Pinto, V., Palmieri, F. (1985) in Achievements and Perspectives of Mitochondria Research, eds. Quagliarielio, E., Slater, E. C., Saccone, C., Palmieri, F., Kroon, A. M. 1:317–327.Google Scholar
  2. Bezrukov, S. M., Vodyanoy, I. (1991) Biophys. J. 59:457a.Google Scholar
  3. Bo, L. and R. E. Waugh (1989) Biophys. J. 55:509–517PubMedCrossRefGoogle Scholar
  4. Coorssen, J. and R. P. Rand (1988) Studia Biophysica 127:53–60Google Scholar
  5. Cowley, A. C., Fuller, N. L. Rand, R. P., Parsegian, V. A. (1978) Biochemistry 17:3163–3168.PubMedCrossRefGoogle Scholar
  6. Colombo, M. F., Rau, D. C., Parsegian, V. A. (1991) Biophys. J. 59: 611a.Google Scholar
  7. Gawrisch, K., Parsegian, V. A., Hajduk, D. A., Tate, M. W., Gruner, S. M., Fuller, N. L. and R. P. Rand (1991) Biophys, J. 59:548a.Google Scholar
  8. Gawrisch, K., Zimmerberg, J., Rushton, D., Rand, R. P. and N. L. Fuller (1990) Biophys. J. 57:35a.Google Scholar
  9. Evans E. and Parsegian, V. A. (1986) Proc. Nat. Acad. Sci. 83:7132–7136.PubMedCrossRefGoogle Scholar
  10. Gruner, S.M. Proc. Natl. Acad. Sci. USA 82, (1985), 3665–3669.PubMedCrossRefGoogle Scholar
  11. Gruner, S. M., Parsegian, V. A. and Rand. R. P. (1986) Discussions Chem. Soc. 81:29–37.CrossRefGoogle Scholar
  12. Helfrich, W. (1978) Z. Naturforsch.33a:305–315.Google Scholar
  13. Hopfield, J. J. (1973) J. Mol. Biol. 77:207–222.PubMedCrossRefGoogle Scholar
  14. Horn, R.G., Israelachvili, J.N., Marra, J., Parsegian, V.A., Rand, R.P. (1988). Biophys. J.Google Scholar
  15. Israelachvili, J.N., Adams, G.E. (1978) J. Chem. Society Faraday Trans 1, 74:975–1001.CrossRefGoogle Scholar
  16. Kachar, B., Fuller, N. L. and R. P. Rand (1986) Biophys. J. 50:779–788.PubMedCrossRefGoogle Scholar
  17. Kasianowicz, J. J., Moore, C. R., Zimmerberg, J., Pasternak, C., Bashford, C. L., Parsegian, V. A. (1991) Biophys. J. 59:458a.Google Scholar
  18. Kauzmann, W. (1959) Adv. Protein Chemistry 14:1–63.CrossRefGoogle Scholar
  19. Kirk, G. L. and S. M. Gruner (1985) J. Phys. (Les Ulis, Fr.) 46:761–769.CrossRefGoogle Scholar
  20. Kornblatt, J. A., Hoa, G. H. B. (1990) Biochemistry 29:9370–9376.PubMedCrossRefGoogle Scholar
  21. Leikin, S., Rau, D. C., Parsegian, V. A. (submitted Phys. rev A) LeNeveu, D. M, Rand, R. P, Parsegian, V. A, Gingell, D. (1977) Biophys. J. 18:209–230.CrossRefGoogle Scholar
  22. LeNeveu, D. M, Rand, R. P, Parsegian, V. A. (1976) Nature 259:601–603.PubMedCrossRefGoogle Scholar
  23. Lis, L. J., McAlister, M., Fuller, N. L., Rand, R. P., Parsegian, V. A., (1982). Biophys.J. 37:657–666.PubMedGoogle Scholar
  24. Loosley-Millman, M. E., Rand, R. P., Parsegian, V. A. (1982). Biophys. J. 40:221–232.PubMedCrossRefGoogle Scholar
  25. Luzzati, V. (1968) in Biological Membranes (Chapman, D. Ed), pp.71–123, Academic Press, New York.Google Scholar
  26. Manella, C. A., Radermacher, M., Frank, F. (1984) Proc. 42nd Electron Micros. Soc. Am. p 664.Google Scholar
  27. Mcintosh, T. J. and Simon, S. A. (1986) Biochemistry 25:4058–4066.PubMedCrossRefGoogle Scholar
  28. Mcintosh, T. J. and Simon, S. A. (1986) Biochemistry 25:4948–4952.PubMedCrossRefGoogle Scholar
  29. Mcintosh, T.J., Magid, A.D., Simon,S.A. (1988). Biochemistry 26: 7325–7332.CrossRefGoogle Scholar
  30. Parsegian, V. A., Fuller, N. L., Rand, R. P. (1979). Proc. Nat. Acad. Sci. USA 76:2750–2754.PubMedCrossRefGoogle Scholar
  31. Parsegian, V.A., Rand, R.P., Fuller, N.L. and Rau, D.C. (1986) in Methods in Enzymology. Vol. 127. Biomembranes; Protons and Water: Structure and Translocation (Packer, L., ed.), pp. 400–416, Academic Press, New YorkCrossRefGoogle Scholar
  32. Pashley, R.M., McGuiggan, P.M., Ninham, B.W., Brady, J. and Evans, D.F. (1986) J. Phys. Chem. 90:1637–1642.CrossRefGoogle Scholar
  33. Podgornik, R., Rau, D.C., Parsegian, V.A. (1989) Macromolecules 22:1780–1786.CrossRefGoogle Scholar
  34. Prouty, M. S., Schecter, A. N., Parsegian, V. A. (1985) J. Mol. Biol. 184:517.PubMedCrossRefGoogle Scholar
  35. Rand, R. P., Fuller, N. L., Lis, L. J. (1979) Nature 279:258–260.PubMedCrossRefGoogle Scholar
  36. Rand, R. P. N.L. Fuller, S.M. Gruner, V.A. Parsegian (1990) Biochemistry 29:76–87PubMedCrossRefGoogle Scholar
  37. Rand, R. P. and V. A. Parsegian (1989) Biochim. Biophys. Acta 988:351–376.Google Scholar
  38. Rand, R. P. and V. A. Parsegian (1986) Ann. Rev. Physiology 48:201–212.CrossRefGoogle Scholar
  39. Rand, R.P. (1981). Ann. Rev. Biophys. Bioeng. 10:277–314.CrossRefGoogle Scholar
  40. Rand, R.P., Fuller, N.L., Parsegian, V.A., Rau, D.C. (1988) Biochemistry 27:7711–7722.PubMedCrossRefGoogle Scholar
  41. Rau, D. C., Lee, B. K., Parsegian, V. A. (1984) Proc. Nat Acad. Sci. USA. 81:2621–2625PubMedCrossRefGoogle Scholar
  42. Rau, D.C. and Parsegian, V.A. (1987) Biophys. J. 51:503CrossRefGoogle Scholar
  43. Rau, D. C., Parsegian, V. A. (1990) Science 249:1278–1281.PubMedCrossRefGoogle Scholar
  44. Safinya, C. R., Smith, E. B., Roux, D., Smith, G. S. (1989) Phys. Rev. Letts. 62:1134–1137.CrossRefGoogle Scholar
  45. Simon, S.A. and T. J. Mcintosh (1989) Proc. Natl. Acad. Sci. USA 86:92639267.Google Scholar
  46. Simon, S.A., Mcintosh, J., Magid, A.D. (in press) J. Colloid & Interface Science.Google Scholar
  47. Starkus, J. G., Rayner, M. D., Ruben, P. C., Alicata, D. A. (1991) Biophys. J. 59:71a.Google Scholar
  48. Zimmerberg, J., Benzanilla F., Parsegian, V. A. (1990) Biophys. J. 57:1049–1064.PubMedCrossRefGoogle Scholar
  49. Zimmerberg, J., Parsegian, V. A. (1986) Nature 323:36–39.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • V. Adrian Parsegian
    • 1
  • R. Peter Rand
    • 2
  • Donald C. Rau
    • 1
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.Biological Sciences Brock UniversitySt. CatharinesCanada

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