Cancer Therapy pp 275-279 | Cite as

Role of Gangliosides in the Modulation of the Angiogenic Response

  • M. Ziche
  • L. Morbidelli
  • A. Parenti
  • G. Alessandri
  • F. Ledda
  • P. M. Gullino
Conference paper
Part of the NATO ASI Series book series (volume 75)

Abstract

The unrestrained growth and metastatic potential of a tumor is strictly correlated to its capacity to induce an efficient capillary network in the host tissue (Folkman J and Cotran R 1976, Ziehe M and Gullino PM, 1982). Under physiological circumstances the ability of a given tissue to produce a neovascular response is under strict controll, i.e. the balance between factors and events favoring or interfering with neovascular growth is in equilibrium.

Keywords

Prostaglandin Macromolecule PGE1 

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References

  1. Alessandri G, Raju KS, Gullino PM (1986) Interaction of gangliosides with fibronectin in the mobilization of capillary endothelium. Invasion Metastasis 6: 145–165.PubMedGoogle Scholar
  2. Alessandri G, De Cristian G, Ziehe M, Cappa APM, Guliino PM (1992) Growth and motility of microvascular endothelium are modulated by the relative concentration of gangliosides in the medium. J Cell Physiol 151: 23–28PubMedCrossRefGoogle Scholar
  3. Alessandri G, Raju KS, Guliino PM (1984) Angiogenesis in vivo and selective mobilization of capillary endothelium in vitro by heparin-copper complex. Microcirculation, Endothelium adn Lymphatics 1: 329–346Google Scholar
  4. De Cristian G, Morbidelli L, Alessandri G, Ziehe M, Cappa APM, Guliino PM (1990) Synergism between gangliosides and basic fibroblast growth factor in favouring survival, growth and motility of capillary endothelium. J Cell Physiol 144: 505–510CrossRefGoogle Scholar
  5. Folkman J, Cotran R (1976) Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol 16: 207.PubMedGoogle Scholar
  6. Folkman J, Klagsburn M (1987) Angiogenic factors. Science 235: 442–447PubMedCrossRefGoogle Scholar
  7. Guliino PM (1981) Angiogenesis factors “in: Baserga R (ed) Handbook Exp Pharmacology” Springer Verlag, New York, 57: 427–449Google Scholar
  8. Langer R, and Folkman J (1976) Polymers for the sustained release of proteins and other macromolecules. Nature 263: 797–800PubMedCrossRefGoogle Scholar
  9. Vlodawskyl, Fuks Z, Ishai-Michael R, Baskin P, Levi E, Korner G, Bar-Shavit R, Klagsburn M (1991) Extracellular-matrix-resident fibroblastic growth factor: implication for control of angiogenesis. J Cell Biochem 45: 167–176CrossRefGoogle Scholar
  10. Ziche M, Jones J, Guliino PM (1982) Role of Prostaglandin E1 and copper in angiogenesis. J Natl Cancer Inst 69: 475–482PubMedGoogle Scholar
  11. Ziche M, and Guliino PM (1982) Angiogenesis and neoplastic progression in vitro. J Natl Cancer Inst 69: 483–487PubMedGoogle Scholar
  12. Ziche M, Alessandri G, Guliino PM (1989) Gangliosides promote the angiogenic response. Lab Inv 61: 629–634Google Scholar
  13. Ziche M, Morbidelli L, Alessandri G, Guliino PM (1992) Angiogenesis can be stimulated in vivo by a change in the GM3.GD3 ganglioside ratio. Lab Inv in press Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. Ziche
    • 1
  • L. Morbidelli
    • 1
  • A. Parenti
    • 1
  • G. Alessandri
    • 1
    • 2
  • F. Ledda
    • 1
  • P. M. Gullino
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of FlorenceFirenzeItaly
  2. 2.Dept. Biol SciencesUniversity of TurinTurinItaly

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